Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli BL21 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E)-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ylidene]butanedioic acid | - |
Homo sapiens | |
(2E)-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ylidene]butanedioic acid | - |
Saccharomyces cerevisiae | |
(2E,4E,8E)-5,9,13-trimethyltetradeca-2,4,8,12-tetraenoic acid | - |
Homo sapiens | |
(2E,4E,8E)-5,9,13-trimethyltetradeca-2,4,8,12-tetraenoic acid | - |
Saccharomyces cerevisiae | |
(2Z)-3-(1H-imidazol-2-yl)-5-methylhexa-2,4-dienoic acid | 8% inhibition at 0.001 M | Saccharomyces cerevisiae | |
(2Z)-5-methyl-3-(1-methyl-1H-imidazol-2-yl)hexa-2,4-dienoic acid | 8% inhibition at 0.001 M | Saccharomyces cerevisiae | |
(2Z,4E)-5,9-dimethyl-3-(1-methyl-1H-imidazol-2-yl)deca-2,4,8-trienoic acid | - |
Homo sapiens | |
(2Z,4E,8E)-5,9,13-trimethyl-3-(1-methyl-1H-imidazol-2-yl)tetradeca-2,4,8,12-tetraenoic acid | - |
Homo sapiens | |
(2Z,4E,8E)-5,9,13-trimethyl-3-(1-methyl-1H-imidazol-2-yl)tetradeca-2,4,8,12-tetraenoic acid | - |
Saccharomyces cerevisiae | |
(4E)-5,9-dimethyl-3-(1-methyl-1H-imidazol-2-yl)deca-4,8-dienoic acid | - |
Homo sapiens | |
(4E,8E)-5,9,13-trimethyl-3-(1-methyl-1H-imidazol-2-yl)tetradeca-4,8,12-trienoic acid | - |
Homo sapiens | |
(4E,8E)-5,9,13-trimethyl-3-(1-methyl-1H-imidazol-2-yl)tetradeca-4,8,12-trienoic acid | - |
Saccharomyces cerevisiae | |
(4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoic acid | - |
Homo sapiens | |
(4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoic acid | - |
Saccharomyces cerevisiae | |
2-[(2E)-3,7-dimethyl-1-(1-methyl-1H-imidazol-2-yl)octa-2,6-dien-1-yl]butanedioic acid | - |
Homo sapiens | |
2-[(2E)-3,7-dimethyl-1-(1-methyl-1H-imidazol-2-yl)octa-2,6-dien-1-yl]butanedioic acid | - |
Saccharomyces cerevisiae | |
2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]butanedioic acid | - |
Homo sapiens | |
2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]butanedioic acid | - |
Saccharomyces cerevisiae | |
3-(1H-imidazol-2-yl)-5-methylhex-4-enoic acid | 21% inhibition at 0.001 M | Saccharomyces cerevisiae | |
5-methyl-3-(1-methyl-1H-imidazol-2-yl)hex-4-enoic acid | 25% inhibition at 0.001 M | Saccharomyces cerevisiae | |
chaetomellic acid A | - |
Homo sapiens | |
chaetomellic acid A | - |
Saccharomyces cerevisiae | |
di-tert-butyl 2-[(2E,6E,10E)-1,3,7-trimethyl-1-(1-methyl-1H-imidazol-2-yl)dodeca-2,6,10-trien-1-yl]butanedioate | - |
Homo sapiens | |
di-tert-butyl 2-[(2E,6E,10E)-1,3,7-trimethyl-1-(1-methyl-1H-imidazol-2-yl)dodeca-2,6,10-trien-1-yl]butanedioate | 50% growth inhibition at 0.03 mM | Plasmodium falciparum | |
di-tert-butyl 2-[(2E,6E,10E)-1,3,7-trimethyl-1-(1-methyl-1H-imidazol-2-yl)dodeca-2,6,10-trien-1-yl]butanedioate | - |
Saccharomyces cerevisiae | |
tert-butyl (2Z,4E,8E)-5,9,13-trimethyl-3-(1-methyl-1H-imidazol-2-yl)tetradeca-2,4,8,12-tetraenoate | - |
Homo sapiens | |
tert-butyl (2Z,4E,8E)-5,9,13-trimethyl-3-(1-methyl-1H-imidazol-2-yl)tetradeca-2,4,8,12-tetraenoate | - |
Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Plasmodium falciparum | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Saccharomyces cerevisiae |
- |
Plasmodium falciparum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + dansyl-GCVLS | assay at pH 7.5, 30°C | Saccharomyces cerevisiae | dansyl-G-(S-(2E,6E)-farnesyl)CVLS + diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine | assay at pH 7.5, 30°C | Homo sapiens | [protein]-S-((2E,6E)-farnesyl)-L-cysteine + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FTase | - |
Homo sapiens |
FTase | - |
Saccharomyces cerevisiae |
FTase | - |
Plasmodium falciparum |
protein farnesyltransferase | - |
Homo sapiens |
protein farnesyltransferase | - |
Saccharomyces cerevisiae |
protein farnesyltransferase | - |
Plasmodium falciparum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
30 | - |
assay at | Saccharomyces cerevisiae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
7.5 | - |
assay at | Saccharomyces cerevisiae |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000175 | - |
30°C, pH 7.5 | Homo sapiens | chaetomellic acid A | |
0.00034 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | chaetomellic acid A | |
0.0025 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | 2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]butanedioic acid | |
0.0054 | - |
30°C, pH 7.5 | Homo sapiens | 2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]butanedioic acid | |
0.0065 | - |
30°C, pH 7.5 | Homo sapiens | (2E)-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ylidene]butanedioic acid | |
0.012 | - |
30°C, pH 7.5 | Homo sapiens | (2Z,4E,8E)-5,9,13-trimethyl-3-(1-methyl-1H-imidazol-2-yl)tetradeca-2,4,8,12-tetraenoic acid | |
0.016 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | (2E)-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ylidene]butanedioic acid | |
0.028 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | (2Z,4E,8E)-5,9,13-trimethyl-3-(1-methyl-1H-imidazol-2-yl)tetradeca-2,4,8,12-tetraenoic acid | |
0.04 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | (2E,4E,8E)-5,9,13-trimethyltetradeca-2,4,8,12-tetraenoic acid | |
0.042 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | (4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoic acid | |
0.13 | - |
30°C, pH 7.5 | Homo sapiens | (2E,4E,8E)-5,9,13-trimethyltetradeca-2,4,8,12-tetraenoic acid | |
0.13 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | (2Z,4E,8E)-5,9,13-trimethyl-3-(1-methyl-1H-imidazol-2-yl)tetradeca-2,4,8,12-tetraenoic acid | |
0.17 | - |
30°C, pH 7.5 | Homo sapiens | (4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoic acid | |
0.175 | - |
30°C, pH 7.5 | Homo sapiens | (2Z,4E,8E)-5,9,13-trimethyl-3-(1-methyl-1H-imidazol-2-yl)tetradeca-2,4,8,12-tetraenoic acid | |
0.3 | - |
30°C, pH 7.5 | Homo sapiens | tert-butyl (2Z,4E,8E)-5,9,13-trimethyl-3-(1-methyl-1H-imidazol-2-yl)tetradeca-2,4,8,12-tetraenoate | |
0.5 | - |
30°C, pH 7.5 | Homo sapiens | (4E,8E)-5,9,13-trimethyl-3-(1-methyl-1H-imidazol-2-yl)tetradeca-4,8,12-trienoic acid | |
0.59 | - |
30°C, pH 7.5 | Homo sapiens | 2-[(2E)-3,7-dimethyl-1-(1-methyl-1H-imidazol-2-yl)octa-2,6-dien-1-yl]butanedioic acid | |
0.6 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | tert-butyl (2Z,4E,8E)-5,9,13-trimethyl-3-(1-methyl-1H-imidazol-2-yl)tetradeca-2,4,8,12-tetraenoate | |
0.7 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | (4E,8E)-5,9,13-trimethyl-3-(1-methyl-1H-imidazol-2-yl)tetradeca-4,8,12-trienoic acid | |
0.7 | - |
30°C, pH 7.5 | Homo sapiens | di-tert-butyl 2-[(2E,6E,10E)-1,3,7-trimethyl-1-(1-methyl-1H-imidazol-2-yl)dodeca-2,6,10-trien-1-yl]butanedioate | |
0.85 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | 2-[(2E)-3,7-dimethyl-1-(1-methyl-1H-imidazol-2-yl)octa-2,6-dien-1-yl]butanedioic acid |