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Literature summary for 2.5.1.58 extracted from

  • Hougland, J.L.; Hicks, K.A.; Hartman, H.L.; Kelly, R.A.; Watt, T.J.; Fierke, C.A.
    Identification of novel peptide substrates for protein farnesyltransferase reveals two substrate classes with distinct sequence selectivities (2010), J. Mol. Biol., 395, 176-190.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.58

Application

Application Comment Organism
medicine farnesyltransferase inhibitors as potential cancer therapeutics Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CALQ + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CALQ + diphosphate
-
 ?
CALV + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CALV + diphosphate
-
 ?
CAVQ + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CAVQ + diphosphate
-
 ?
CCIF + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CCIF + diphosphate
-
 ?
CCIL + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CCIL + diphosphate
-
 ?
CDVK + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CDVK + diphosphate
-
 ?
CEIQ + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CEIQ + diphosphate
-
 ?
CFLS + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CFLS + diphosphate
-
 ?
CFPS + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CFPS + diphosphate
-
 ?
CFTN + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CFTN + diphosphate
-
 ?
CFVN + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CFVN + diphosphate
-
 ?
CGIA + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CGIA + diphosphate
-
 ?
CGIM + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CGIM + diphosphate
-
 ?
CGLF + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CGLF + diphosphate
-
 ?
CGLY + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CGLY + diphosphate
-
 ?
CGVV + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CGVV + diphosphate
-
 ?
CHIM + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CHIM + diphosphate
-
 ?
CHIQ + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CHIQ + diphosphate
-
 ?
CHLM + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CHLM + diphosphate
-
 ?
CHLS + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CHLS + diphosphate
-
 ?
CHVM + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CHVM + diphosphate
-
 ?
CHVQ + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CHVQ + diphosphate
-
 ?
CIVA + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CIVA + diphosphate
-
 ?
CKIF + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CKIF + diphosphate
-
 ?
CKIS + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CKIS + diphosphate
-
 ?
CKIV + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CKIV + diphosphate
-
 ?
CLIT + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CLIT + diphosphate
-
 ?
CLLM + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CLLM + diphosphate
-
 ?
CLLV + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CLLV + diphosphate
-
 ?
CLML + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CLML + diphosphate
-
 ?
CLTS + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CLTS + diphosphate
-
 ?
CLVM + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CLVM + diphosphate
-
 ?
CNIM + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CNIM + diphosphate
-
 ?
CNLF + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CNLF + diphosphate
-
 ?
CNLK + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CNLK + diphosphate
-
 ?
CNLM + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CNLM + diphosphate
-
 ?
CNLQ + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CNLQ + diphosphate
-
 ?
CQTA + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CQTA + diphosphate
-
 ?
CRIS + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CRIS + diphosphate
-
 ?
CSFM + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CSFM + diphosphate
-
 ?
CSIM + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CSIM + diphosphate
-
 ?
CSIS + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CSIS + diphosphate
-
 ?
CSLA + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CSLA + diphosphate
-
 ?
CSLC + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CSLC + diphosphate
-
 ?
CSLG + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CSLG + diphosphate
-
 ?
CSLH + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CSLH + diphosphate
-
 ?
CSLM + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CSLM + diphosphate
-
 ?
CSVQ + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CSVQ + diphosphate
-
 ?
CSVS + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CSVS + diphosphate
-
 ?
CTII + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CTII + diphosphate
-
 ?
CTIV + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CTIV + diphosphate
-
 ?
CTKF + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CTKF + diphosphate
-
 ?
CTLA + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CTLA + diphosphate
-
 ?
CTLM + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CTLM + diphosphate
-
 ?
CTLQ + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CTLQ + diphosphate
-
 ?
CTMS + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CTMS + diphosphate
-
 ?
CTTQ + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CTTQ + diphosphate
-
 ?
CTVF + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CTVF + diphosphate
-
 ?
CTVS + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CTVS + diphosphate
-
 ?
CTVV + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CTVV + diphosphate
-
 ?
CVHF + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CVHF + diphosphate
-
 ?
CVLA + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CVLA + diphosphate
-
 ?
CVLH + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CVLH + diphosphate
-
 ?
CVLQ + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CVLQ + diphosphate
-
 ?
CVQM + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CVQM + diphosphate
-
 ?
CVVT + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CVVT + diphosphate
-
 ?
CYIS + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CYIS + diphosphate
-
 ?
CYLA + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CYLA + diphosphate
-
 ?
CYPD + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CYPD + diphosphate
-
 ?
CYVM + (2E,6E)-farnesyl diphosphate assay at pH 7.8, 25°C Rattus norvegicus S-(2E,6E)-farnesyl-CYVM + diphosphate
-
 ?
farnesyl diphosphate + [protein]-L-cysteine assay at pH 7.8, 25°C Rattus norvegicus [protein]-S-((2E,6E)-farnesyl)-L-cysteine + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
FTase
-
 Rattus norvegicus
protein farnesyltransferase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
 assay at Rattus norvegicus

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.09
-
 CGVV assay at pH 7.8, 25°C Rattus norvegicus
0.092
-
 CTII assay at pH 7.8, 25°C Rattus norvegicus
0.1
-
 CALV assay at pH 7.8, 25°C Rattus norvegicus
0.1
-
 CLLV assay at pH 7.8, 25°C Rattus norvegicus
0.15
-
 CLML assay at pH 7.8, 25°C Rattus norvegicus
0.15
-
 CVLH assay at pH 7.8, 25°C Rattus norvegicus
0.16
-
 CGIA assay at pH 7.8, 25°C Rattus norvegicus
0.17
-
 CKIF assay at pH 7.8, 25°C Rattus norvegicus
0.17
-
 CNLF assay at pH 7.8, 25°C Rattus norvegicus
0.21
-
 CSLH assay at pH 7.8, 25°C Rattus norvegicus
0.22
-
 CLTS assay at pH 7.8, 25°C Rattus norvegicus
0.24
-
 CSLC assay at pH 7.8, 25°C Rattus norvegicus
0.24
-
 CSLG assay at pH 7.8, 25°C Rattus norvegicus
0.27
-
 CVQM assay at pH 7.8, 25°C Rattus norvegicus
0.27
-
 CVVT assay at pH 7.8, 25°C Rattus norvegicus
0.32
-
 CCIL assay at pH 7.8, 25°C Rattus norvegicus
0.36
-
 CTLA assay at pH 7.8, 25°C Rattus norvegicus
0.39
-
 CSFM assay at pH 7.8, 25°C Rattus norvegicus
0.44
-
 CIVA assay at pH 7.8, 25°C Rattus norvegicus
0.45
-
 CGLF assay at pH 7.8, 25°C Rattus norvegicus
0.46
-
 CHLS assay at pH 7.8, 25°C Rattus norvegicus
0.46
-
 CVHF assay at pH 7.8, 25°C Rattus norvegicus
0.5
-
 CVLA assay at pH 7.8, 25°C Rattus norvegicus
0.53
-
 CQTA assay at pH 7.8, 25°C Rattus norvegicus
0.53
-
 CTMS assay at pH 7.8, 25°C Rattus norvegicus
0.6
-
 CFLS assay at pH 7.8, 25°C Rattus norvegicus
0.67
-
 CNLQ assay at pH 7.8, 25°C Rattus norvegicus
0.71
-
 CTTQ assay at pH 7.8, 25°C Rattus norvegicus
0.78
-
 CVLQ assay at pH 7.8, 25°C Rattus norvegicus
0.87
-
 CKIV assay at pH 7.8, 25°C Rattus norvegicus
0.9
-
 CYPD assay at pH 7.8, 25°C Rattus norvegicus
0.97
-
 CFTN assay at pH 7.8, 25°C Rattus norvegicus
1
-
 CGLY assay at pH 7.8, 25°C Rattus norvegicus
1
-
 CNLM assay at pH 7.8, 25°C Rattus norvegicus
1.1
-
 CTLM assay at pH 7.8, 25°C Rattus norvegicus
1.1
-
 CGIM assay at pH 7.8, 25°C Rattus norvegicus
1.2
-
 CSVQ assay at pH 7.8, 25°C Rattus norvegicus
1.3
-
 CTVF assay at pH 7.8, 25°C Rattus norvegicus
1.7
-
 CLLM assay at pH 7.8, 25°C Rattus norvegicus
1.8
-
 CSLM assay at pH 7.8, 25°C Rattus norvegicus
1.8
-
 CSVS assay at pH 7.8, 25°C Rattus norvegicus
1.9
-
 CTLQ assay at pH 7.8, 25°C Rattus norvegicus
2
-
 CHLM assay at pH 7.8, 25°C Rattus norvegicus
2.1
-
 CFVN assay at pH 7.8, 25°C Rattus norvegicus
2.1
-
 CNIM assay at pH 7.8, 25°C Rattus norvegicus
2.2
-
 CHIQ assay at pH 7.8, 25°C Rattus norvegicus
2.3
-
 CTVV assay at pH 7.8, 25°C Rattus norvegicus
2.5
-
 CLIT assay at pH 7.8, 25°C Rattus norvegicus
2.5
-
 CSLA assay at pH 7.8, 25°C Rattus norvegicus
2.5
-
 CYVM assay at pH 7.8, 25°C Rattus norvegicus
2.7
-
 CSIS assay at pH 7.8, 25°C Rattus norvegicus
2.8
-
 CKIS assay at pH 7.8, 25°C Rattus norvegicus
3
-
 CCIF assay at pH 7.8, 25°C Rattus norvegicus
3.1
-
 CEIQ assay at pH 7.8, 25°C Rattus norvegicus
3.3
-
 CHIM assay at pH 7.8, 25°C Rattus norvegicus
3.6
-
 CDVK assay at pH 7.8, 25°C Rattus norvegicus
3.8
-
 CRIS assay at pH 7.8, 25°C Rattus norvegicus
4.4
-
 CTKF assay at pH 7.8, 25°C Rattus norvegicus
4.5
-
 CHVQ assay at pH 7.8, 25°C Rattus norvegicus
4.7
-
 CFPS assay at pH 7.8, 25°C Rattus norvegicus
4.7
-
 CYLA assay at pH 7.8, 25°C Rattus norvegicus
5.8
-
 CTVS assay at pH 7.8, 25°C Rattus norvegicus
6
-
 CLVM assay at pH 7.8, 25°C Rattus norvegicus
6.3
-
 CNLK assay at pH 7.8, 25°C Rattus norvegicus
7.2
-
 CTIV assay at pH 7.8, 25°C Rattus norvegicus
10
-
 CHVM assay at pH 7.8, 25°C Rattus norvegicus
12
-
 CALQ assay at pH 7.8, 25°C Rattus norvegicus
12
-
 CYIS assay at pH 7.8, 25°C Rattus norvegicus
14
-
 CSIM assay at pH 7.8, 25°C Rattus norvegicus
44
-
 CAVQ assay at pH 7.8, 25°C Rattus norvegicus