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Literature summary for 2.5.1.6 extracted from

  • Avila, M.A.; Corrales, F.J.; Ruiz, F.; Sanchez-Gongora, E.; Mingorance, J.; Carretero, M.V.; Mato, J.M.
    Specific interaction of methionine adenosyltransferase with free radicals (1998), Biofactors, 8, 27-32.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-morpholinosydnoniimide loss of liver MAT activity in vivo Rattus norvegicus
bacterial lipopolysaccharide decreases MAT activity in vivo Rattus norvegicus
hydrogen peroxide inactives CHO cells-MAT, prevented by desferoxamine. Time- and dose-dependent inactivation of MAT I/III, activity recovered by addition of glutathione Rattus norvegicus
L-buthionine-(S,R)-sulfoximine inhibits glutathione synthesis and this decreases MAT activity in vivo. Prevented by the administration of glutathione-ethyl ester Rattus norvegicus
additional information MAT is inactivated after 6 h of incubation in hypoxia (3% O2) in rat hepatocytes, prevented by NG-monomethyl-L-arginine methyl ester. Hepatic MAT s a sensible target for free radicals in vivo Rattus norvegicus
S-nitrosylated glutathione rapid and dose-dependent loss of enzymatic activity of MAT I/III Rattus norvegicus
SIN-1 rapid and dose-dependent loss of enzymatic activity of MAT I/III Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-methionine + H2O Rattus norvegicus MAT activity controls cellular glutathione levels, polyamine synthesis and folate cycling S-adenosyl-L-methionine + phosphate + diphosphate
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-methionine + H2O MAT activity controls cellular glutathione levels, polyamine synthesis and folate cycling Rattus norvegicus S-adenosyl-L-methionine + phosphate + diphosphate
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?