Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-morpholinosydnoniimide | loss of liver MAT activity in vivo | Rattus norvegicus | |
bacterial lipopolysaccharide | decreases MAT activity in vivo | Rattus norvegicus | |
hydrogen peroxide | inactives CHO cells-MAT, prevented by desferoxamine. Time- and dose-dependent inactivation of MAT I/III, activity recovered by addition of glutathione | Rattus norvegicus | |
L-buthionine-(S,R)-sulfoximine | inhibits glutathione synthesis and this decreases MAT activity in vivo. Prevented by the administration of glutathione-ethyl ester | Rattus norvegicus | |
additional information | MAT is inactivated after 6 h of incubation in hypoxia (3% O2) in rat hepatocytes, prevented by NG-monomethyl-L-arginine methyl ester. Hepatic MAT s a sensible target for free radicals in vivo | Rattus norvegicus | |
S-nitrosylated glutathione | rapid and dose-dependent loss of enzymatic activity of MAT I/III | Rattus norvegicus | |
SIN-1 | rapid and dose-dependent loss of enzymatic activity of MAT I/III | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-methionine + H2O | Rattus norvegicus | MAT activity controls cellular glutathione levels, polyamine synthesis and folate cycling | S-adenosyl-L-methionine + phosphate + diphosphate | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-methionine + H2O | MAT activity controls cellular glutathione levels, polyamine synthesis and folate cycling | Rattus norvegicus | S-adenosyl-L-methionine + phosphate + diphosphate | - |
? |