Literature summary for 2.5.1.6 extracted from

Panayiotidis, M.I.; Stabler, S.P.; Ahmad, A.; Pappa, A.; Legros, L.H.; Hernandez-Saavedra, D.; Schneider, B.K.; Allen, R.H.; Vasiliou, V.; McCord, J.M.; Kotb, M.; White, C.W.
Activation of a novel isoform of methionine adenosyl transferase 2A and increased S-adenosylmethionine turnover in lung epithelial cells exposed to hyperoxia (2006), Free Radic. Biol. Med., 40, 348-358.

Search for more literature for 2.5.1.6

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	cell methionine and S-adenosylmethionine contents increase in response to hyperoxia in SAE and A549 cells, enzyme activity increases by 2fold within 5 days, S-adenosylmethionine content by 5fold, overview	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
cloning and sequencing of the MAT 2A cDNA from lung epithelial cells reveals one silent nucleotide substitution compared to that expressed in Jurkat cells	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
K+	-	Homo sapiens
Mg2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-methionine + H2O	Homo sapiens	rate-limiting enzyme of the S-adenosyl-L-methionine synthesis pathway, cell methionine and S-adenosylmethionine contents increase in response to hyperoxia in SAE and A549 cells, overview	phosphate + diphosphate + S-adenosyl-L-methionine	-	?
additional information	Homo sapiens	transmethylation and transsulfuration pathways, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P31153	lung epithelial isoform and Jurkat cell isozyme of MAT 2A	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
epithelial cell	lung epithelial isoform of MAT 2A	Homo sapiens	-
JURKAT cell	Jurkat cell isoform of MAT 2A	Homo sapiens	-
lung	lung epithelial isoform of MAT 2A, epithelial-like and primary small airway epithelial, SAE, cells	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-methionine + H2O	-	Homo sapiens	phosphate + diphosphate + S-adenosyl-L-methionine	-	?
ATP + L-methionine + H2O	rate-limiting enzyme of the S-adenosyl-L-methionine synthesis pathway, cell methionine and S-adenosylmethionine contents increase in response to hyperoxia in SAE and A549 cells, overview	Homo sapiens	phosphate + diphosphate + S-adenosyl-L-methionine	-	?
additional information	transmethylation and transsulfuration pathways, overview	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
MAT	-	Homo sapiens
methionine adenosyl transferase 2A	-	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)