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Literature summary for 2.5.1.60 extracted from
- Protein prenyltransferases (1996), J. Biol. Chem., 271, 5289-5292.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 38000 | - |
alpha,beta, 1 * 60000 + 1 * 38000 | Saccharomyces cerevisiae |
| 60000 | - |
alpha,beta, 1 * 60000 + 1 * 38000 | Saccharomyces cerevisiae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate | enzyme is unique in the protein prenyltransferase family, consisting protein farnesyltransferase, EC 2.5.1.58, protein geranylgeranyltransferase type I, EC 2.5.1.59 and Rab geranylgeranyltransferase | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| geranylgeranyl diphosphate + protein-cysteine | enzyme attaches geranylgeranyl groups to two C-terminal cysteines in Ras-related GTPases of a single family, the Rab family, Ypt/Sec4 in lower eukaryotes, that terminate in XXCC, XCXC and CCXX motifs, reaction only if Rab is bound to a carrier protein termed Rab escort protein, REP | Saccharomyces cerevisiae | S-geranylgeranyl-protein + diphosphate | - |
? |  |
| geranylgeranyl diphosphate + protein-cysteine | Rab protein forms a stable complex with Rab escort protein, REP | Saccharomyces cerevisiae | S-geranylgeranyl-protein + diphosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | alpha,beta, 1 * 60000 + 1 * 38000 | Saccharomyces cerevisiae |
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