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Literature summary for 2.5.1.60 extracted from

  • Wilson, A.L.; Erdman, R.A.; Castellano, F.; Maltese, W.A.
    Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases (1998), Biochem. J., 333, 497-504.
No PubMed abstract available
Search for more literature for 2.5.1.60

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
geranylgeranyl diphosphate + protein-cysteine Bos taurus the Rab protein Rab8-GTPase, which end with a Cys-Val-Leu-Leu motif able to serve as a substrate for either geranylgeranyl transferase I and II, but modified predominantly by either geranylgeranyl transferase II in vivo S-geranylgeranyl-protein + diphosphate
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geranylgeranyl diphosphate + protein-cysteine Bos taurus reaction is critical for membrane localization of Rab proteins and for their interaction with soluble regulatory proteins S-geranylgeranyl-protein + diphosphate
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Organism

Organism UniProt Comment Textmining
Bos taurus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate + protein-cysteine enzyme attaches geranylgeranyl groups to two C-terminal cysteines in Ras-related GTPases of a single family, the Rab family, Ypt/Sec4 in lower eukaryotes, that terminate in XXCC, XCXC and CCXX motifs, reaction only if Rab is bound to a carrier protein termed Rab escort protein, REP Bos taurus S-geranylgeranyl-protein + diphosphate
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geranylgeranyl diphosphate + protein-cysteine Rab protein forms a stable complex with Rab escort protein, REP Bos taurus S-geranylgeranyl-protein + diphosphate
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geranylgeranyl diphosphate + protein-cysteine the Rab protein Rab8-GTPase, which end with a Cys-Val-Leu-Leu motif able to serve as a substrate for either geranylgeranyl transferase I and II, but modified predominantly by either geranylgeranyl transferase II in vivo Bos taurus S-geranylgeranyl-protein + diphosphate
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geranylgeranyl diphosphate + protein-cysteine reaction is critical for membrane localization of Rab proteins and for their interaction with soluble regulatory proteins Bos taurus S-geranylgeranyl-protein + diphosphate
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geranylgeranyl diphosphate + Rab1B
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 Bos taurus ?
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geranylgeranyl diphosphate + Rab8 the Rab protein Rab8-GTPase, which end with a Cys-Val-Leu-Leu motif able to serve as a substrate for either geranylgeranyl transferase I and II, but modified predominantly by either geranylgeranyl transferase II in vitro, but the mutation of Y78D prevents Rab8 from serving as a substrate Bos taurus ?
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