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Literature summary for 2.5.1.60 extracted from
- Double prenylation by RabGGTase can proceed without dissociation of the mono-prenylated intermediate (2001), J. Biol. Chem., 276, 48631-48636.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in SF21 cells | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate | mechanism, phosphoisoprenoid acts both as a substrate and as a sensor governing the kinetics of protein protein interactions in the double prenylation reaction | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| geranylgeranyl diphosphate + protein-cysteine | - |
Rattus norvegicus | S-geranylgeranyl-protein + diphosphate | - |
? |  |
| additional information | the affinity of the mono-prenylated Rab7/REP-1 complex is very close to that observed for double prenylated Rab7/REP-1 complex binding to enzyme | Rattus norvegicus | ? | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | double prenylation the rate for the first prenyl transfer reaction is 0.00026/min, while the second prenyl transfer reaction is 4fold slower | Rattus norvegicus |
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Release 2023.1 (January 2023)
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