Cloned (Comment) | Organism |
---|---|
expression in SF21 cells | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranylgeranyl diphosphate + protein-cysteine | Rattus norvegicus | this posttranslational modification is essential for the biological activity of Rab proteins | S-geranylgeranyl-protein + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate | enzyme is unique in the protein prenyltransferase family, consisting protein farnesyltransferase, EC 2.5.1.58, protein geranylgeranyltransferase type I, EC 2.5.1.59 and Rab geranylgeranyltransferase | Rattus norvegicus | |
geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate | mechanism, geranylgeranyl diphosphate first acts as an allosteric regulator of enzyme, second acts as the phosphoisoprenoid donor in the prenylation reaction and third senses the completion of catalysis and concomitantly triggers substrate release by increasing the dissociation rate of the product | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranylgeranyl diphosphate + protein-cysteine | - |
Rattus norvegicus | S-geranylgeranyl-protein + diphosphate | - |
? | |
geranylgeranyl diphosphate + protein-cysteine | this posttranslational modification is essential for the biological activity of Rab proteins | Rattus norvegicus | S-geranylgeranyl-protein + diphosphate | - |
? |