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Literature summary for 2.5.1.61 extracted from
- The enzymatic conversion of porphobilinogen to uroporphyrinogen catalyzed by extracts of hematopoietic mouse spleen (1967), J. Biol. Chem., 242, 4248-4253.
No PubMed abstract available
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.037 | - |
porphobilinogen | 60°C | Mus musculus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| porphobilinogen | Mus musculus | - |
? | - |
? | |
| porphobilinogen | Spinacia oleracea | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Spinacia oleracea | - |
spinach | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| spleen | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4 porphobilinogen | in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 | Spinacia oleracea | uroporphyrinogen III + 4 NH3 | - |
? | |
| 4 porphobilinogen | in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 | Mus musculus | uroporphyrinogen III + 4 NH3 | uroporphyrinogen III cosynthase is more heat-labile than porphobilinogen deaminase. Heat-treatment of the porphobilinogen deaminase/uroporphyrinogen III cosynthase enzyme system forms only 2-4% of uroporphyrinogen III | ? | |
| 4 porphobilinogen + H2O | - |
Mus musculus | hydroxylmethylbilane + 4 NH3 | uroporphyrinogen I | ? | |
| 4 porphobilinogen + H2O | - |
Mus musculus | hydroxylmethylbilane + 4 NH3 | uroporphyrinogen | ? | |
| 4 porphobilinogen + H2O | - |
Spinacia oleracea | hydroxylmethylbilane + 4 NH3 | uroporphyrinogen | ? | |
| porphobilinogen | - |
Mus musculus | ? | - |
? | |
| porphobilinogen | - |
Spinacia oleracea | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| uroporphyrinogen I synthetase | - |
Mus musculus |
| uroporphyrinogen I synthetase | - |
Spinacia oleracea |
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Release 2023.1 (January 2023)
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