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Literature summary for 2.5.1.61 extracted from
- Comparative inhibition of hepatic hydroxymethylbilane synthase by both hard and soft metal cations (1984), Can. J. Biochem. Cell Biol., 62, 49-54.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Al3+ | - |
Rattus norvegicus |  |
| Ba2+ | - |
Rattus norvegicus | |
| Cd2+ | strong | Rattus norvegicus | |
| Co2+ | - |
Rattus norvegicus | |
| Cr3+ | strong | Rattus norvegicus | |
| Cu2+ | strong | Rattus norvegicus | |
| Fe3+ | strong | Rattus norvegicus | |
| Hg2+ | strong | Rattus norvegicus | |
| Mg2+ | - |
Rattus norvegicus | |
| Mn2+ | - |
Rattus norvegicus | |
| additional information | - |
Rattus norvegicus | |
| Na+ | - |
Rattus norvegicus | |
| Ni2+ | - |
Rattus norvegicus | |
| Pb2+ | strong | Rattus norvegicus | |
| UO22+ | - |
Rattus norvegicus | |
| VO2+ | - |
Rattus norvegicus | |
| Zn2+ | strong | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| porphobilinogen | Rattus norvegicus | - |
? | - |
? | |
| porphobilinogen | Rattus norvegicus Sprague-Dawley | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Sprague-Dawley | - |
| Rattus norvegicus Sprague-Dawley | - |
Sprague-Dawley | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4 porphobilinogen | in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 | Rattus norvegicus | uroporphyrinogen III + 4 NH3 | - |
? | |
| 4 porphobilinogen | in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 | Rattus norvegicus Sprague-Dawley | uroporphyrinogen III + 4 NH3 | - |
? | |
| 4 porphobilinogen + H2O | - |
Rattus norvegicus | hydroxylmethylbilane + 4 NH3 | - |
? | |
| 4 porphobilinogen + H2O | - |
Rattus norvegicus Sprague-Dawley | hydroxylmethylbilane + 4 NH3 | - |
? | |
| porphobilinogen | - |
Rattus norvegicus | ? | - |
? | |
| porphobilinogen | - |
Rattus norvegicus Sprague-Dawley | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HMB-S | - |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | 7.3 | - |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.2 | 8.4 | pH 6.2: 50% of maximal activity, pH 8.4: 30% of maximal activity | Rattus norvegicus |
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