Protein Variants | Comment | Organism |
---|---|---|
additional information | antisense-based modulation of murA1 gene expression, which encodes UDP-N-acetylglucosamine enolpyruvyl transferase, hypersensitizes cells to the MurA-specific antibiotic fosfomycin despite the normally high resistance of Bacillus anthracis to this drug | Bacillus anthracis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fosfomycin | - |
Bacillus anthracis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus anthracis | - |
isoforms MurA1, murA2 | - |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
in wild-type background, IC50 of fosfomycin is 2,048 microg/ml. In a strain with antisense-based expression attenuation of the MurA1 gene encoding UDP-N-acetylglucosamine enolpyruvyl transferase, IC50 value is 126 microg/ml. Prsence of xylose further decreases the IC50 value to 18 microg/ml | Bacillus anthracis | additional information |