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Literature summary for 2.5.1.75 extracted from

  • Spinola, M.; Galvan, A.; Pignatiello, C.; Conti, B.; Pastorino, U.; Nicander, B.; Paroni, R.; Dragani, T.A.
    Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer (2005), Oncogene, 24, 5502-5509.
    View publication on PubMed

Application

Application Comment Organism
medicine expression of full-length transcript is downregulated 6-14fold in lung adenocarcinomas compared to normal tissue. A549-cells transfected to express the functional enzyme form significantly smaller colonies with reduced scattering on the edges and have only limited ability to induce tumors in nude mice Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q3T7C6
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-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
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Homo sapiens
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lung normal and tumor tissue Homo sapiens
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Synonyms

Synonyms Comment Organism
TRIT1
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Homo sapiens
tRNA-IPT
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Homo sapiens