Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(E)-3-hydroxy-4-(2-(5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-yl)vinyl)benzoic acid | - |
Mycobacterium tuberculosis | |
(E)-3-hydroxy-4-(2-(5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-yl)vinyl)benzoic acid | - |
Schizosaccharomyces pombe | |
(E)-4-(2-(5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-yl)vinyl)benzoate | - |
Schizosaccharomyces pombe | |
(E)-4-(2-(5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-yl)vinyl)benzoic acid | - |
Mycobacterium tuberculosis | |
(E)-5-nitro-6-(2-hydroxystyryl)pyrimidine-2,4(1H,3H)-dione | competitive | Mycobacterium tuberculosis | |
(E)-5-nitro-6-(2-hydroxystyryl)pyrimidine-2,4(1H,3H)-dione | competitive | Schizosaccharomyces pombe | |
(E)-5-nitro-6-(3-(pyridin-3-yl)vinyl)pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-5-nitro-6-(3-nitrostyryl)pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-5-nitro-6-(3-nitrostyryl)pyrimidine-2,4(1H,3H)-dione | - |
Schizosaccharomyces pombe | |
(E)-5-nitro-6-(4-bromostyryl)pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-5-nitro-6-(4-nitrostyryl)pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-5-nitro-6-(4-nitrostyryl)pyrimidine-2,4(1H,3H)-dione | - |
Schizosaccharomyces pombe | |
(E)-5-nitro-6-[2-(1H-pyrrol-2-yl)vinyl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-5-nitro-6-[2-(1H-pyrrol-2-yl)vinyl]pyrimidine-2,4(1H,3H)-dione | - |
Schizosaccharomyces pombe | |
(E)-6-(2,3,4-trimethoxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-6-(2,3-dihydroxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-6-(2,3-dihydroxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Schizosaccharomyces pombe | |
(E)-6-(2,3-dimethoxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-6-(2,3-dimethoxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Schizosaccharomyces pombe | |
(E)-6-(2-(3H-indol-3-yl)vinyl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-6-(2-(3H-indol-3-yl)vinyl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Schizosaccharomyces pombe | |
(E)-6-(2-(naphthalen-2-yl)vinyl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-6-(2-(naphthalen-2-yl)vinyl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Schizosaccharomyces pombe | |
(E)-6-(2-fluoro-3-methoxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-6-(2-fluoro-3-methoxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Schizosaccharomyces pombe | |
(E)-6-(2-fluorostyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-6-(2-hydroxy-3-nitrostyryl)-3-nitropyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-6-(2-hydroxy-5-nitrostyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-6-(2-methoxy-5-nitrostyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-6-(2-methoxy-5-nitrostyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Schizosaccharomyces pombe | |
(E)-6-(2-methoxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-6-(2-methoxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Schizosaccharomyces pombe | |
(E)-6-(2-nitrostyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-6-(3,4,5-trimethoxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-6-(3,4-dimethoxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-6-(3-hydroxy-4-methoxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-6-(3-hydroxy-4-nitrostyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-6-(3-hydroxy-4-nitrostyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Schizosaccharomyces pombe | |
(E)-6-(3-hydroxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | competitive | Mycobacterium tuberculosis | |
(E)-6-(4-chlorostyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-6-(4-fluorostyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-6-(4-hydroxy-3-nitrostyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
(E)-6-(4-hydroxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
5-nitro-6-styryluracil | - |
Mycobacterium tuberculosis | |
5-nitro-6-styryluracil | - |
Schizosaccharomyces pombe |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Schizosaccharomyces pombe | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.113 | - |
- |
Schizosaccharomyces pombe |
0.113 | - |
- |
Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate | penultimate step of riboflavin biosynthesis | Mycobacterium tuberculosis | 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate | - |
? | |
5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate | - |
Schizosaccharomyces pombe | 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
27 | - |
assay at | Schizosaccharomyces pombe |
27 | - |
assay at | Mycobacterium tuberculosis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Schizosaccharomyces pombe |
7 | - |
assay at | Mycobacterium tuberculosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0037 | - |
(E)-5-nitro-6-(4-nitrostyryl)pyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.0049 | - |
(E)-6-(2,3-dihydroxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Schizosaccharomyces pombe | |
0.0071 | - |
(E)-6-(3-hydroxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.0078 | - |
(E)-6-(2-fluorostyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.0096 | - |
(E)-6-(2,3-dimethoxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.011 | - |
(E)-6-(2-(naphthalen-2-yl)vinyl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.011 | - |
(E)-5-nitro-6-(3-nitrostyryl)pyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Schizosaccharomyces pombe | |
0.012 | - |
(E)-6-(2,3-dihydroxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.012 | - |
(E)-6-(3-hydroxy-4-nitrostyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.012 | - |
(E)-6-(4-hydroxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.013 | - |
(E)-5-nitro-6-(4-nitrostyryl)pyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Schizosaccharomyces pombe | |
0.013 | - |
(E)-5-nitro-6-[2-(1H-pyrrol-2-yl)vinyl]pyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Schizosaccharomyces pombe | |
0.015 | - |
5-nitro-6-styryluracil | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.016 | - |
(E)-6-(2-nitrostyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.017 | - |
(E)-6-(3,4,5-trimethoxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.023 | - |
(E)-6-(2-methoxy-5-nitrostyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.024 | - |
(E)-6-(2-fluoro-3-methoxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.026 | - |
(E)-5-nitro-6-(4-bromostyryl)pyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.026 | - |
(E)-5-nitro-6-(3-(pyridin-3-yl)vinyl)pyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.028 | - |
(E)-6-(2-methoxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.03 | - |
(E)-5-nitro-6-[2-(1H-pyrrol-2-yl)vinyl]pyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.031 | - |
(E)-6-(2-hydroxy-5-nitrostyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.032 | - |
(E)-6-(3,4-dimethoxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.035 | - |
(E)-4-(2-(5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-yl)vinyl)benzoic acid | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.041 | - |
(E)-4-(2-(5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-yl)vinyl)benzoate | pH 7.0, 27°C | Schizosaccharomyces pombe | |
0.042 | - |
(E)-5-nitro-6-(3-nitrostyryl)pyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.042 | - |
(E)-6-(2-hydroxy-3-nitrostyryl)-3-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.045 | - |
(E)-6-(4-chlorostyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.048 | - |
(E)-6-(2,3,4-trimethoxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.052 | - |
(E)-6-(3-hydroxy-4-methoxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.07 | - |
(E)-6-(2-(3H-indol-3-yl)vinyl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.085 | - |
(E)-6-(2-methoxy-5-nitrostyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Schizosaccharomyces pombe | |
0.086 | - |
(E)-6-(4-fluorostyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.087 | - |
(E)-6-(4-hydroxy-3-nitrostyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.094 | - |
(E)-6-(3-hydroxy-4-nitrostyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Schizosaccharomyces pombe | |
0.094 | - |
(E)-6-(2-(naphthalen-2-yl)vinyl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Schizosaccharomyces pombe | |
0.095 | - |
(E)-5-nitro-6-(2-hydroxystyryl)pyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.13 | - |
(E)-3-hydroxy-4-(2-(5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-yl)vinyl)benzoic acid | pH 7.0, 27°C | Schizosaccharomyces pombe | |
0.141 | - |
(E)-6-(2-(3H-indol-3-yl)vinyl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Schizosaccharomyces pombe | |
0.143 | - |
5-nitro-6-styryluracil | pH 7.0, 27°C | Schizosaccharomyces pombe | |
0.151 | - |
(E)-6-(2-fluoro-3-methoxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Schizosaccharomyces pombe | |
0.197 | - |
(E)-3-hydroxy-4-(2-(5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-yl)vinyl)benzoic acid | pH 7.0, 27°C | Mycobacterium tuberculosis | |
0.205 | - |
(E)-6-(2-methoxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Schizosaccharomyces pombe | |
0.21 | - |
(E)-5-nitro-6-(2-hydroxystyryl)pyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Schizosaccharomyces pombe | |
0.243 | - |
(E)-6-(2,3-dimethoxystyryl)-5-nitropyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Schizosaccharomyces pombe |