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Literature summary for 2.5.1.9 extracted from

  • Cushman, M.; Yang, D.; Mihalic, J.T.; Chen, J.; Gerhardt, S.; Huber, R.; Fischer, M.; Kis, K.; Bacher, A.
    Incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase vs lumazine synthase (2002), J. Org. Chem., 67, 6871-6877.
    View publication on PubMed
Search for more literature for 2.5.1.9

Cloned(Commentary)

Cloned (Comment) Organism
-
 Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
modeling for the binding of two molecules of inhibitor 5-(4-phosphonobutyryl)amino-6-D-ribitylaminouracil in the active site Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
5-(4-phosphonobutyryl)amino-6-D-ribitylaminouracil comparison with inhibition of Bacillus subtilis luminazine synthase/riboflavin synthase Escherichia coli
5-(4-phosphonopentyryl)amino-6-D-ribitylaminouracil comparison with inhibition of Bacillus subtilis luminazine synthase/riboflavin synthase Escherichia coli
5-(5-phosphonoxyvaleryl)amino-6-D-ribitylaminouracil mixed inhibition, comparison with inhibition of Bacillus subtilis luminazine synthase/riboflavin synthase Escherichia coli
5-(hexyl 6-dihydrogen phosphate)-6-([(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]amino)pyrimidine-2,4(1H,3H)-dione mixed inhibition, comparison with inhibition of Bacillus subtilis luminazine synthase/riboflavin synthase Escherichia coli
additional information incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase versus lumazine synthase Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0068
-
 5-(4-phosphonopentyryl)amino-6-D-ribitylaminouracil pH 7.5, 37°C Escherichia coli
0.16
-
 5-(4-phosphonobutyryl)amino-6-D-ribitylaminouracil pH 7.5, 37°C Escherichia coli
0.19
-
 5-(5-phosphonoxyvaleryl)amino-6-D-ribitylaminouracil pH 7.5, 37°C Escherichia coli
1
-
 5-(hexyl 6-dihydrogen phosphate)-6-([(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]amino)pyrimidine-2,4(1H,3H)-dione pH 7.5, 37°C Escherichia coli