Any feedback?
Literature summary for 2.5.1.94 extracted from
- The fluorinase, the chlorinase and the duf-62 enzymes (2008), Curr. Opin. Chem. Biol., 12, 582-592.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| G131S | the mutation results in instability and arrested chlorination | Salinispora tropica |
| Y70T | the mutation leads to a 1000fold loss of chlorination activity | Salinispora tropica |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Salinispora tropica | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | although this enzyme utilises bromide and even iodide it does not fluorinate | Salinispora tropica | ? | - |
? |  |
| S-adenosyl-L-methionine + chloride | - |
Salinispora tropica | 5'-deoxy-5'-chloroadenosine + L-methionine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homotrimer | x-ray crystallography | Salinispora tropica |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| chlorinase | - |
Salinispora tropica |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | a chlorinase knockout mutated strain of Salinispora tropica is able to biosynthesis the fluorinated analogue of salinosporamide A, when the medium was supplemented with 5-deoxy-5-fluoroadenosine | Salinispora tropica |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
