Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Staphylococcus aureus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(S)-1-phosphono-4-(3-phenoxyphenyl)butylsulfonic acid | far more active than (R)-compound both in vitro an in cells | Staphylococcus aureus | |
1-phosphono-4-[3-(3,4-difluorophenoxy)phenyl]butylsulfonic acid | - |
Staphylococcus aureus | |
1-phosphono-4-[3-(3-fluorophenoxy)phenyl]butylsulfonic acid | - |
Staphylococcus aureus | |
1-phosphono-4-[3-(4-fluorophenoxy)phenyl]butylsulfonic acid | - |
Staphylococcus aureus | |
1-phosphono-4-[3-(4-propylphenoxy)phenyl]butylsulfonic acid | potent inhibitor in cell-based assay | Staphylococcus aureus | |
4-(4-biphenyl)butyldiphosphonic acid | - |
Staphylococcus aureus | |
4-[4-(4-trifluoromethylphenyl)phenyl]butyldiphosphonic acid | - |
Staphylococcus aureus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | A9JQL9 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
CrtM | - |
Staphylococcus aureus |
dehydrosqualene synthase | - |
Staphylococcus aureus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0002 | - |
pH 7.4, 20°C | Staphylococcus aureus | 4-[4-(4-trifluoromethylphenyl)phenyl]butyldiphosphonic acid | |
0.0005 | - |
pH 7.4, 20°C | Staphylococcus aureus | 4-(4-biphenyl)butyldiphosphonic acid | |
0.0014 | - |
pH 7.4, 20°C | Staphylococcus aureus | (S)-1-phosphono-4-(3-phenoxyphenyl)butylsulfonic acid | |
0.0021 | - |
pH 7.4, 20°C | Staphylococcus aureus | 1-phosphono-4-[3-(3-fluorophenoxy)phenyl]butylsulfonic acid | |
0.0022 | - |
pH 7.4, 20°C | Staphylococcus aureus | 1-phosphono-4-[3-(4-propylphenoxy)phenyl]butylsulfonic acid | |
0.0022 | - |
pH 7.4, 20°C | Staphylococcus aureus | 1-phosphono-4-[3-(3,4-difluorophenoxy)phenyl]butylsulfonic acid | |
0.0023 | - |
pH 7.4, 20°C | Staphylococcus aureus | 1-phosphono-4-[3-(4-fluorophenoxy)phenyl]butylsulfonic acid |