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Literature summary for 2.6.1.1 extracted from

  • Guidetti, P.; Amori, L.; Sapko, M.T.; Okuno, E.; Schwarcz, R.
    Mitochondrial aspartate aminotransferase: a third kynurenate-producing enzyme in the mammalian brain (2007), J. Neurochem., 102, 103-111.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
alpha-aminoadipate IC50: 1.5 mM Rattus norvegicus
aspartate IC50: 0.3 mM Rattus norvegicus
glutamate IC50: 0.9 mM Rattus norvegicus
additional information insensitive to glutamine Rattus norvegicus
quisqualate 6 mM, 90% inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.724
-
L-kynurenine at pH 7.4 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Mus musculus 5739
-
mitochondrion
-
Homo sapiens 5739
-
mitochondrion
-
Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
DEAE-Sepharose column chromatography and Phenyl-Sepharose column chromatography Mus musculus
DEAE-Sepharose column chromatography and Phenyl-Sepharose column chromatography Rattus norvegicus
isoenzyme mitAAT DEAE-Sepharose column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
brain
-
Homo sapiens
-
brain
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00000967
-
enzyme from homogenate Rattus norvegicus
0.00875
-
after 905fold purification Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-aspartate + 2-oxoglutarate
-
Mus musculus oxaloacetate + L-glutamate
-
?
L-aspartate + 2-oxoglutarate
-
Homo sapiens oxaloacetate + L-glutamate
-
?
L-aspartate + 2-oxoglutarate
-
Rattus norvegicus oxaloacetate + L-glutamate
-
?
L-kynurenine + ?
-
Mus musculus kynurenic acid + ?
-
?
L-kynurenine + ?
-
Homo sapiens kynurenic acid + ?
-
?
L-kynurenine + ?
-
Rattus norvegicus kynurenic acid + ?
-
?

Synonyms

Synonyms Comment Organism
AAT
-
Mus musculus
AAT
-
Homo sapiens
AAT
-
Rattus norvegicus
aspartate aminotransferase
-
Mus musculus
aspartate aminotransferase
-
Homo sapiens
aspartate aminotransferase
-
Rattus norvegicus
KAT IV
-
Rattus norvegicus
mitAAT
-
Mus musculus
mitAAT
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Mus musculus
8
-
-
Homo sapiens
8
-
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.3
-
IC50: 0.3 mM Rattus norvegicus aspartate
0.9
-
IC50: 0.9 mM Rattus norvegicus glutamate
1.5
-
IC50: 1.5 mM Rattus norvegicus alpha-aminoadipate