Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-aminoadipate | IC50: 1.5 mM | Rattus norvegicus | |
aspartate | IC50: 0.3 mM | Rattus norvegicus | |
glutamate | IC50: 0.9 mM | Rattus norvegicus | |
additional information | insensitive to glutamine | Rattus norvegicus | |
quisqualate | 6 mM, 90% inhibition | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.724 | - |
L-kynurenine | at pH 7.4 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
DEAE-Sepharose column chromatography and Phenyl-Sepharose column chromatography | Mus musculus |
DEAE-Sepharose column chromatography and Phenyl-Sepharose column chromatography | Rattus norvegicus |
isoenzyme mitAAT DEAE-Sepharose column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Homo sapiens | - |
brain | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00000967 | - |
enzyme from homogenate | Rattus norvegicus |
0.00875 | - |
after 905fold purification | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-aspartate + 2-oxoglutarate | - |
Mus musculus | oxaloacetate + L-glutamate | - |
? | |
L-aspartate + 2-oxoglutarate | - |
Homo sapiens | oxaloacetate + L-glutamate | - |
? | |
L-aspartate + 2-oxoglutarate | - |
Rattus norvegicus | oxaloacetate + L-glutamate | - |
? | |
L-kynurenine + ? | - |
Mus musculus | kynurenic acid + ? | - |
? | |
L-kynurenine + ? | - |
Homo sapiens | kynurenic acid + ? | - |
? | |
L-kynurenine + ? | - |
Rattus norvegicus | kynurenic acid + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AAT | - |
Mus musculus |
AAT | - |
Homo sapiens |
AAT | - |
Rattus norvegicus |
aspartate aminotransferase | - |
Mus musculus |
aspartate aminotransferase | - |
Homo sapiens |
aspartate aminotransferase | - |
Rattus norvegicus |
KAT IV | - |
Rattus norvegicus |
mitAAT | - |
Mus musculus |
mitAAT | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Mus musculus |
8 | - |
- |
Homo sapiens |
8 | - |
- |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.3 | - |
IC50: 0.3 mM | Rattus norvegicus | aspartate | |
0.9 | - |
IC50: 0.9 mM | Rattus norvegicus | glutamate | |
1.5 | - |
IC50: 1.5 mM | Rattus norvegicus | alpha-aminoadipate |