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Literature summary for 2.6.1.108 extracted from

  • Wang, Y; Xu, H; Jones, MK; White, R.H.
    Identification of the final two genes functioning in methanofuran biosynthesis in Methanocaldococcus jannaschii (2015), J. Bacteriol., 197, 2850-2858.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Methanocaldococcus jannaschii
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gene mfnC
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-alanine + 4-(hydroxymethyl)-2-furancarboxaldehyde-phosphate
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Methanocaldococcus jannaschii pyruvate + 5-(aminomethyl)-3-furanmethanol-phosphate
-
?

Synonyms

Synonyms Comment Organism
mfnC
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Methanocaldococcus jannaschii

General Information

General Information Comment Organism
evolution all methanofuran structural variants contain a basic core structure of 4-[N-(gamma-L-glutamyl)-p-(bet-aminoethyl)phenoxymethyl]-(aminomethyl)furan (APMF-Glu) but have different side chains depending on the source organism Methanocaldococcus jannaschii
metabolism the four genes mfnA, mfnB, mfnC, and mfnD are responsible for the biosynthesis of the methanofuran precursor gamma-glutamyltyramine and 5-(aminomethyl)-3-furanmethanol-phosphate from tyrosine, glutamate, glyceraldehyde-3-phosphate, and alanine in Methanocaldococcus jannaschii, overview Methanocaldococcus jannaschii