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Literature summary for 2.6.1.13 extracted from

  • Gafan, C.; Wilson, J.; Berger, L.C.; Berger, B.J.
    Characterization of the ornithine aminotransferase from Plasmodium falciparum (2001), Mol. Biochem. Parasitol., 118, 1-10.
    View publication on PubMed
Search for more literature for 2.6.1.13

Cloned(Commentary)

Cloned (Comment) Organism
calmodulin-binding peptide fusion protein Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
L-canaline aminooxy analogue of ornithine Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.56
-
 2-oxoglutarate pH 7.4, 37°C Plasmodium falciparum
1.53
-
 N-acetylornithine pH 7.4, 37°C Plasmodium falciparum
3.95
-
 L-ornithine pH 7.4, 37°C Plasmodium falciparum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
 2 * 45000, SDS-PAGE, homodimer Plasmodium falciparum
109000
-
 gel filtration Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
 3D7
-

Purification (Commentary)

Purification (Comment) Organism
-
 Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine + 2-oxoglutarate
-
 Plasmodium falciparum DELTA1-pyrroline-5-carboxylate + L-glutamate
-
 ?
N-acetylornithine + 2-oxoglutarate
-
 Plasmodium falciparum glutamate + N-acetyl-glutamate-gammasemialdehyde
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 45000, SDS-PAGE, homodimer Plasmodium falciparum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000492
-
 L-canaline pH 7.4, 37°C Plasmodium falciparum