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Literature summary for 2.6.1.13 extracted from
- Sex-differential expression of ornithine aminotransferase in the mouse kidney (2007), Am. J. Physiol. Renal Physiol., 292, F1016-F1027.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | before puberty, ornithine aminotransferase expression is similar between female and male kidneys whereas from puberty until adulthood ornithine aminotransferase expression increases in the female kidney, becoming 2.5fold higher than in the male kidney. This sex-differential expression of ornithine aminotransferase is associated with a sex-specific distribution of enzyme along the corticopapillary axis and within the nephron. Ornithine aminotransferase is three- to fourfold more expressed in the female than the male cortex. In males, enzyme is highly expressed in the medulla, mainly in the thick ascending limbs. Renal enzyme distribution in orchidectomized mice resembles that in the females. Ovariectomy does not influence enzyme expression. Ornithine aminotransferase is naturally downregulated in the presence of testosterone | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| testosterone | ornithine aminotransferase is naturally downregulated in the presence of testosterone | Mus musculus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Mus musculus | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 48000 | - |
SDS-PAGE | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P29758 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Mus musculus | - |
| kidney | before puberty, ornithine aminotransferase expression is similar between female and male kidneys whereas from puberty until adulthood ornithine aminotransferase expression increases in the female kidney, becoming 2.5fold higher than in the male kidney. This sex-differential expression of ornithine aminotransferase is associated with a sex-specific distribution of enzyme along the corticopapillary axis and within the nephron. Ornithine aminotransferase is three- to fourfold more expressed in the female than the male cortex. In males, enzyme is highly expressed in the medulla, mainly in the thick ascending limbs. Renal enzyme distribution in orchidectomized mice resembles that in the females. Ovariectomy does not influence enzyme expression. Ornithine aminotransferase is naturally downregulated in the presence of testosterone | Mus musculus | - |
| renal cortex | highest expression in female mice | Mus musculus | - |
| renal medulla | highest expression in male mice | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-ornithine + 2-oxoglutarate | - |
Mus musculus | DELTA1-pyrroline-5-carboxylate + L-glutamate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| OAT | - |
Mus musculus |
| ornithine aminotransferase | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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