Literature summary for 2.6.1.13 extracted from

Markova, M.; Peneff, C.; Hewlins, M.J.; Schirmer, T.; John, R.A.
Determinants of substrate specificity in omega-aminotransferases (2005), J. Biol. Chem., 280, 36409-36416.

Search for more literature for 2.6.1.13

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
E235A	mutant retains its regiospecificity for the gamma-amino group of ornithine, but the glutamate reaction is enhanced 650fold, whereas only a 5fold enhancement of the ketoglutarate reaction rate results	Homo sapiens
E235S	mutation leads to a lowering of the apparent rate and an increase of the dissociation constant	Homo sapiens
Y85I	mutation greatly affects the ketoglutarate reaction but has no effect on the glutamate reaction	Homo sapiens
Y85L	significant decrease in reactivity toward ornithine	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P04181	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-ornithine + 2-oxoglutarate	-	Homo sapiens	DELTA1-pyrroline-5-carboxylate + L-glutamate	-	r

Synonyms

Synonyms	Comment	Organism
Orn-AT	-	Homo sapiens
ornithine aminotransferase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	0.02 mM, required for activity	Homo sapiens

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Release 2023.1 (January 2023)