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Literature summary for 2.6.1.16 extracted from

  • McKnight, G.L.; Mudri, S.L.; Mathewes, S.L.; Traxinger, R.R.; Marshall, S.; Sheppard, P.O.; O'Hara, P.J.
    Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase (1992), J. Biol. Chem., 267, 25208-25212.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
77000
-
? * 77000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamine + D-fructose 6-phosphate Homo sapiens enzyme plays a key role in induction of insulin resistance in cultured cells L-glutamate + D-glucosamine 6-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamine + D-fructose 6-phosphate
-
Homo sapiens L-glutamate + D-glucosamine 6-phosphate
-
?
L-glutamine + D-fructose 6-phosphate enzyme plays a key role in induction of insulin resistance in cultured cells Homo sapiens L-glutamate + D-glucosamine 6-phosphate
-
?

Subunits

Subunits Comment Organism
? ? * 77000, SDS-PAGE Homo sapiens
More The fact that the 77 kDa protein expressed in Escherichia coli is sensitive to inhibition by UDP-N-acetylglucosamine is consistent with the idea that mammalian GFAT is comprised of four identical subunits Homo sapiens