Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.6.1.16 extracted from

  • Milewski, S.; Janiak, A.; Wojciechowski, M.
    Structural analogues of reactive intermediates as inhibitors of glucosamine-6-phosphate synthase and phosphoglucose isomerase (2006), Arch. Biochem. Biophys., 450, 39-49.
    View publication on PubMed
Search for more literature for 2.6.1.16

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae strain YRS C-65 Candida albicans

Inhibitors

Inhibitors Comment Organism Structure
2-amino-2-deoxy-D-glucitol-6-phosphate
-
 Candida albicans
2-amino-2-deoxy-D-glucitol-6-phosphate dimethyl ester
-
 Candida albicans
2-amino-2-deoxy-D-mannitol-6-phosphate
-
 Candida albicans
5-phospho-D-arabinoamide
-
 Candida albicans
N-acetyl-2-amino-2-deoxy-D-glucitol-6-phosphate
-
 Candida albicans

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Candida albicans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamine + D-fructose 6-phosphate
-
 Candida albicans L-glutamate + D-glucosamine 6-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
GlcN-6-P synthase
-
 Candida albicans
glucosamine-6-phosphate synthase
-
 Candida albicans
L-glutamine:D-fructose-6-phosphate amidotransferase (hexose isomerizing)
-
 Candida albicans

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.009
-
 2-amino-2-deoxy-D-mannitol-6-phosphate
-
 Candida albicans
0.035
-
 2-amino-2-deoxy-D-glucitol-6-phosphate
-
 Candida albicans
0.62
-
 5-phospho-D-arabinoamide
-
 Candida albicans
0.68
-
 2-amino-2-deoxy-D-glucitol-6-phosphate dimethyl ester
-
 Candida albicans
0.84
-
 N-acetyl-2-amino-2-deoxy-D-glucitol-6-phosphate
-
 Candida albicans