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Literature summary for 2.6.1.22 extracted from
- Identity of beta-alanine-oxo-glutarate aminotransferase and L-beta-aminoisobutyrate aminotransferase in rat liver (1987), Biochim. Biophys. Acta, 925, 238-240.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (S)-3-amino-2-methylpropanoate | beta-alanine as substrate, not (R)-isomer | Rattus norvegicus |  |
| Antiserum against beta-alanine:2-oxoglutarate aminotransferase | - |
Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.7 | - |
(S)-3-amino-2-methylpropanoate | pH 8.8, 37°C | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Rattus norvegicus | 5737 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-3-amino-2-methylpropanoate + 2-oxoglutarate | Rattus norvegicus | involved in omega-amino acid metabolism in mammals | 2-methyl-3-oxopropanoate + L-glutamate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male Sprague Dawley | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-3-amino-2-methylpropanoate + 2-oxoglutarate | i.e. L-beta-aminoisobutyrate, not D-isomer | Rattus norvegicus | 2-methyl-3-oxopropanoate + L-glutamate | - |
? | |
| (S)-3-amino-2-methylpropanoate + 2-oxoglutarate | involved in omega-amino acid metabolism in mammals | Rattus norvegicus | 2-methyl-3-oxopropanoate + L-glutamate | - |
? | |
| beta-alanine + 2-oxoglutarate | as good as (S)-3-amino-2-methylpropanoate | Rattus norvegicus | malonic semialdehyde + L-glutamate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.7 | - |
(S)-3-amino-2-methylpropanoate | pH 8.8, 37°C | Rattus norvegicus | |
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