KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.25 | - |
L-2-aminoadipate | pH 8.0, 37°C isoenzyme AadAT-II | Homo sapiens | |
1 | - |
2-oxoadipate | pH 8.0, 37°C isoenzyme AadAT-II | Homo sapiens | |
1.1 | - |
2-oxoglutarate | pH 8.0, 37°C isoenzyme AadAT-I | Homo sapiens | |
1.4 | - |
glutamate | pH 8.0, 37°C | Homo sapiens | |
2.5 | - |
2-oxoadipate | pH 8.0, 37°C isoenzyme AadAT-I | Homo sapiens | |
3.2 | - |
2-oxoglutarate | pH 8.0, 37°C isoenzyme AadAT-II | Homo sapiens | |
12.5 | - |
L-glutamate | pH 8.0, 37°C, isoenzyme AadAT-II | Homo sapiens | |
20 | - |
L-2-aminoadipate | pH 8.0, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | isoenzyme AadAT-I | Homo sapiens | 5737 | - |
cytosol | - |
Homo sapiens | 5829 | - |
mitochondrion | isoenzyme AadAT-II | Homo sapiens | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
46000 | - |
2 * 46000, SDS-PAGE | Homo sapiens |
98000 | - |
isoenzyme AadAT-II, sucrose density gradient centrifugation | Homo sapiens |
104000 | - |
isoenzyme AadAT-I, sucrose density gradient centrifugation | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-2-aminoadipate + 2-oxoglutarate | Homo sapiens | lysine and tryptophan metabolism | 2-oxoadipate + L-glutamate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Purification (Comment) | Organism |
---|---|
2 isoenzymes, AadAT-I and AadAT-II | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.77 | - |
isoenzyme AadAT-I | Homo sapiens |
10.68 | - |
isoenzyme AadAT-II | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
kynurenine + 2-oxoglutarate | - |
Homo sapiens | kynurenic acid + L-glutamate | - |
ir | |
L-2-aminoadipate + 2-oxoglutarate | - |
Homo sapiens | 2-oxoadipate + L-glutamate | - |
r | |
L-2-aminoadipate + 2-oxoglutarate | lysine and tryptophan metabolism | Homo sapiens | 2-oxoadipate + L-glutamate | - |
r | |
L-tryptophan + 2-oxoglutarate | - |
Homo sapiens | 3-indole-2-oxopropanoate + L-glutamate | - |
? | |
additional information | 2 isoenzymes, AadAT-I and AadAT-II, isoenzyme AadAT-II shows additional activity with tryptophan or kynurenine-2-oxoglutarate reaction, only slight activity with asparagine, alanine, arginine, ornithine, isoleucine, valine, leucine, lysine, serine, threonine, phenylalanine, tyrosine, histidine, glutamine, methionine or aspartate with 2-oxoglutarate | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 46000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
AadAT | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9 | 9.5 | isoenzyme AadAT-II | Homo sapiens |
9.5 | - |
isoenzyme AadAT-I | Homo sapiens |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
9 | 9.5 | isoenzyme AadAT-I, sensitive to pH changes, activity is quickly lost at a higher pH, isoenzyme AadAT-II is less sensitive to pH changes | Homo sapiens |