Any feedback?
Literature summary for 2.6.1.40 extracted from
- Inhibition of D-3-aminoisobutyrate-pyruvate aminotransferase by 5-fluorouracil and alpha-fluoro-beta-alanine (1992), Biochim. Biophys. Acta, 1122, 45-49.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-Bromouracil | 1 M | Rattus norvegicus |  |
| 5-Chlorouracil | 0.1 mM | Rattus norvegicus | |
| 5-Diazouracil | 1 M | Rattus norvegicus | |
| 5-fluorouracil | strong, kinetics | Rattus norvegicus | |
| 5-fluorouridine | weak | Rattus norvegicus | |
| 5-Iodouracil | 1 M | Rattus norvegicus | |
| 5-Nitrouracil | 0.1 M | Rattus norvegicus | |
| 5-Thiouracil | 1 M, not 2-thiouracil | Rattus norvegicus | |
| alpha-fluoro-beta-alanine | kinetics | Rattus norvegicus | |
| Isoorotic acid | 1 M | Rattus norvegicus | |
| additional information | no inhibitor: aminouracil; no inhibitor: precursors of beta-alanine or (R)-3-amino-2-methylpropanoate, i.e. orotic acid, uracil, thymine | Rattus norvegicus | |
| pyruvate | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
