Cloned (Comment) | Organism |
---|---|
His-tagged protein expressed in Escherichia coli JM109, expressed in CHO cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
DELTA 1-21 | purified protein does not show bound PLP (affinity is about 80fold lower than wild type protein), catalytic activity about 1000fold lower than wild type protein, expressed in Escherichia coli in an insoluble form, peroxisomal localization, expressed in CHO cells the mutant protein forms large stable but catalytically inactive aggregates in the peroxisomes | Homo sapiens |
P10L/P11L | Kcat value 56% of wild type protein, aggregation occuring at a slower rate than that of DELTA 1-21 protein | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | - |
Homo sapiens | 5777 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-alanine + glyoxylate | - |
Homo sapiens | pyruvate + glycine | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | gel filtration | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
alanine:glyoxylate aminotransferase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | causes the hereditary kidney stone disease primary hyperoxaluria type 1 | Homo sapiens |