Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4-hydroxyphenyl)acetic acid | 74% inhibition with tyrosine at 3 mM and (4-hydroxyphenyl)acetic acid at 12 mM | Rattus norvegicus | |
3,4-dihydroxyphenylalanine | - |
Rattus norvegicus | |
3-(3,4-Dihydroxyphenyl)-2-methylalanine | - |
Rattus norvegicus | |
3-methoxydopamine | - |
Rattus norvegicus | |
3-Methoxytyrosine | - |
Rattus norvegicus | |
5-hydroxyindole acetic acid | 55% inhibition with tyrosine at 3 mM and 5-hydroxyindole acetic acid at 12 mM | Rattus norvegicus | |
5-hydroxytryptophan | 30% inhibition with tyrosine at 3 mM and 5-hydroxytryptophan at 12 mM | Rattus norvegicus | |
alpha-Methyltyrosine | - |
Rattus norvegicus | |
D-tyrosine | 9% inhibition with tyrosine at 3 mM and D-tyrosine at 12 mM | Rattus norvegicus | |
dihydroxymandelic acid | 65% inhibition with tyrosine at 3 mM and dihydroxymandelic acid at 3 mM | Rattus norvegicus | |
dihydroxyphenylacetic acid | 88% inhibition with tyrosine at 3 mM and dihydroxyphenylacetic acid at 3 mM | Rattus norvegicus | |
dopamine | 100% inhibition with tyrosine at 3 mM and dopamine at 12 mM | Rattus norvegicus | |
homovanillic acid | - |
Rattus norvegicus | |
indole-3-acetic acid | 42% inhibition with tyrosine at 3 mM and indole-3-acetic acid at 12 mM | Rattus norvegicus | |
indole-3-butyric acid | 71% inhibition with tyrosine at 3 mM and indole-3-butyric acid at 12 mM | Rattus norvegicus | |
Indole-3-propionic acid | 48% inhibition with tyrosine at 3 mM and indole-3-propionic acid at 12 mM | Rattus norvegicus | |
norepinephrine | competitive inhibition | Rattus norvegicus | |
normetanephrine | - |
Rattus norvegicus | |
phenylacetic acid | 30% inhibition with tyrosine at 3 mM and phenylacetic acid at 12 mM | Rattus norvegicus | |
Phenylethylamine | 80% inhibition with tyrosine at 3 mM and phenylethylamine at 12 mM | Rattus norvegicus | |
serotonin | 37% inhibition with tyrosine at 3 mM and serotonin at 12 mM | Rattus norvegicus | |
tyramine | 13% inhibition with tyrosine at 3 mM and tyramine at 12 mM | Rattus norvegicus | |
vanillylmandelic acid | 51% inhibition with tyrosine at 3 mM and vanillylmandelic acid at 3 mM | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
15 | - |
L-tyrosine | pH 7.9, 37°C | Rattus norvegicus | |
26 | - |
3,4-dihydroxyphenylalanine | pH 7.9, 37°C | Rattus norvegicus | |
30 | - |
tryptophan | pH 7.9, 37°C | Rattus norvegicus | |
80 | - |
phenylalanine | pH 7.9, 37°C | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
effect of induction with hydrocortisone on activity | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2-aminophenyl)alanine + 2-oxoglutarate | 10% of the activity that with L-tyrosine | Rattus norvegicus | 3-(4-aminophenyl)-2-oxopropanoate + L-glutamate | - |
? | |
(3-fluorophenyl)alanine + 2-oxoglutarate | 4% of the activity that with L-tyrosine | Rattus norvegicus | 3-(3-fluorophenyl)-2-oxopropanoate + L-glutamate | - |
? | |
(4-fluorophenyl)alanine + 2-oxoglutarate | 7.9% of the activity that with L-tyrosine | Rattus norvegicus | 3-(4-fluorophenyl)-2-oxopropanoate + L-glutamate | - |
? | |
3,4-dihydroxyphenylalanine + 2-oxoglutarate | - |
Rattus norvegicus | 3-(3,4-dihydroxyphenyl)-2-oxopropanoate + L-glutamate | - |
? | |
3-aminotyrosine + 2-oxoglutarate | 16% of the activity than with L-tyrosine | Rattus norvegicus | 3-(3-amino-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate | - |
? | |
3-iodotyrosine + 2-oxoglutarate | as effective as L-tyrosine | Rattus norvegicus | 3-(4-hydroxy-3-iodophenyl)-2-oxopropanoate + L-glutamate | - |
? | |
L-phenylalanine + 2-oxoglutarate | lower activity than with L-tyrosine | Rattus norvegicus | phenylpyruvate + L-glutamate | - |
? | |
L-tyrosine + 2-oxoglutarate | maximal activity with L-tyrosine | Rattus norvegicus | 4-hydroxyphenylpyruvate + L-glutamate | - |
? | |
tryptophan + 2-oxoglutarate | - |
Rattus norvegicus | 3-indole-2-oxopropanoate + L-glutamate | - |
? |