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Literature summary for 2.6.1.51 extracted from
- Pyridoxal 5'-phosphate binding of a recombinant rat serine: pyruvate/alanine:glyoxylate aminotransferase (1996), J. Biochem., 119, 970-978.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| glucagon | mitochondrial enzyme is markedly induced by | Rattus norvegicus |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| cDNA cloned and expressed in Escherichia coli DH1 | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| peroxisome | - |
Rattus norvegicus | 5777 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 44400 | - |
2 * 44400, recombinant enzyme, SDS-PAGE | Rattus norvegicus |
| 80000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-serine + pyruvate | Rattus norvegicus | - |
3-hydroxypyruvate + L-alanine | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant enzyme | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 4.62 | - |
recombinant enzyme | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-alanine + glyoxylate | - |
Rattus norvegicus | pyruvate + glycine | - |
? | |
| L-serine + pyruvate | - |
Rattus norvegicus | 3-hydroxypyruvate + L-alanine | - |
r | |
| additional information | class IV aminotransferase, identical with EC 2.6.1.44 | Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Rattus norvegicus |
| homodimer | 2 * 44400, recombinant enzyme, SDS-PAGE | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| serine:pyruvate/alanine:glyoxylate aminotransferase | - |
Rattus norvegicus |
| SPT/AGT | - |
Rattus norvegicus |
| SPT10 | recombinant enzyme | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
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