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Literature summary for 2.6.1.51 extracted from

  • Noguchi, T.; Takada, Y.; Kido, R.
    Characteristics of hepatic serine-pyruvate aminotransferase in different mammalian species (1977), Biochem. J., 161, 609-614.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.6.1.51

Inhibitors

Inhibitors Comment Organism Structure
hydroxylamine
-
 Canis lupus familiaris
hydroxylamine
-
 Felis catus
hydroxylamine
-
 Mus musculus
hydroxylamine
-
 Rattus norvegicus
Isonicotinic acid hydrazide
-
 Mus musculus
Isonicotinic acid hydrazide
-
 Rattus norvegicus
additional information not inhibited by isonicotinic acid hydrazide Canis lupus familiaris
additional information not inhibited by isonicotinic acid hydrazide Felis catus
Semicarbazide
-
 Canis lupus familiaris
Semicarbazide
-
 Felis catus
Semicarbazide
-
 Mus musculus
Semicarbazide
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1
-
 pyruvate pH 8.0, 37°C, serine as amino donor Rattus norvegicus
1.2
-
 pyruvate pH 8.0, 37°C, serine as amino donor Mus musculus
1.6
-
 pyruvate pH 8.0, 37°C, serine as amino donor Felis catus
1.7
-
 pyruvate pH 8.0, 37°C, serine as amino donor Canis lupus familiaris
8
-
 serine pH 8.0, 37°C, pyruvate as amino acceptor Canis lupus familiaris
10
-
 serine pH 8.0, 37°C, pyruvate as amino acceptor Felis catus
16
-
 serine pH 8.0, 37°C, pyruvate as amino acceptor Rattus norvegicus
18
-
 serine pH 8.0, 37°C, pyruvate as amino acceptor Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-
mitochondrion
-
 Canis lupus familiaris 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
73000 79000 sucrose density gradient centrifugation Mus musculus
73000 79000 sucrose density gradient centrifugation Rattus norvegicus
73000 79000 sucrose density gradient centrifugation Canis lupus familiaris
73000 79000 sucrose density gradient centrifugation Felis catus
75000 80000 gel filtration Mus musculus
75000 80000 gel filtration Rattus norvegicus
75000 80000 gel filtration Canis lupus familiaris
75000 80000 gel filtration Felis catus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-serine + pyruvate Mus musculus gluconeogenesis from serine 3-hydroxypyruvate + L-alanine
-
 r
L-serine + pyruvate Rattus norvegicus gluconeogenesis from serine 3-hydroxypyruvate + L-alanine
-
 r
L-serine + pyruvate Canis lupus familiaris gluconeogenesis from serine 3-hydroxypyruvate + L-alanine
-
 r
L-serine + pyruvate Felis catus gluconeogenesis from serine 3-hydroxypyruvate + L-alanine
-
 r

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
 dog
-
Felis catus
-
-
-
Mus musculus
-
 mouse
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus
-
 Rattus norvegicus
-
 Canis lupus familiaris
-
 Felis catus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-
liver
-
 Rattus norvegicus
-
liver
-
 Canis lupus familiaris
-
liver
-
 Felis catus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.02
-
 alanine-hydroxypyruvate transamination Rattus norvegicus
2.23
-
 alanine-hydroxypyruvate transamination Mus musculus
3.58
-
 serine-pyruvate transamination Mus musculus
4.08
-
 serine-pyruvate transamination Rattus norvegicus
13
-
 serine-pyruvate transamination Canis lupus familiaris
13.12
-
-
 Canis lupus familiaris
14
-
 serine-pyruvate transamination Felis catus
16.63
-
 alanine-hydroxypyruvate transamination Felis catus
31.38
-
 alanine-hydroxypyruvate transamination Canis lupus familiaris

Storage Stability

Storage Stability Organism
-20°C, 50 mM potassium phosphate buffer, pH 7.5, containing 0.1 M pyridoxal 5'-phosphate, may be stored for at least 4 weeks without loss of activity Mus musculus
-20°C, 50 mM potassium phosphate buffer, pH 7.5, containing 0.1 M pyridoxal 5'-phosphate, may be stored for at least 4 weeks without loss of activity Canis lupus familiaris
-20°C, 50 mM potassium phosphate buffer, pH 7.5, containing 0.1 M pyridoxal 5'-phosphate, may be stored for at least 4 weeks without loss of activity Felis catus
0-6°C, 50 mM potassium phosphate buffer, pH 7.5, containing 0.1 M pyridoxal 5'-phosphate, little loss with storage for at least 2 weeks Mus musculus
0-6°C, 50 mM potassium phosphate buffer, pH 7.5, containing 0.1 M pyridoxal 5'-phosphate, little loss with storage for at least 2 weeks Canis lupus familiaris
0-6°C, 50 mM potassium phosphate buffer, pH 7.5, containing 0.1 M pyridoxal 5'-phosphate, little loss with storage for at least 2 weeks Felis catus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-hydroxytryptophan + pyruvate
-
 Mus musculus 3-(5-hydroxyindole)-2-oxopropanoate + alanine
-
 ?
5-hydroxytryptophan + pyruvate
-
 Rattus norvegicus 3-(5-hydroxyindole)-2-oxopropanoate + alanine
-
 ?
asparagine + pyruvate
-
 Mus musculus 2-oxosuccinamate + L-alanine
-
 ?
asparagine + pyruvate
-
 Rattus norvegicus 2-oxosuccinamate + L-alanine
-
 ?
glutamine + pyruvate
-
 Mus musculus 4-carbamoyl-2-oxobutanoate + L-alanine
-
 ?
glutamine + pyruvate
-
 Rattus norvegicus 4-carbamoyl-2-oxobutanoate + L-alanine
-
 ?
histidine + pyruvate
-
 Mus musculus 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
-
 ?
histidine + pyruvate
-
 Rattus norvegicus 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
-
 ?
isoleucine + pyruvate
-
 Mus musculus 3-methyl-2-oxopentanoate + alanine
-
 ?
L-alanine + 3-hydroxypyruvate
-
 Mus musculus pyruvate + L-serine
-
 r
L-alanine + 3-hydroxypyruvate
-
 Rattus norvegicus pyruvate + L-serine
-
 r
L-alanine + 3-hydroxypyruvate
-
 Canis lupus familiaris pyruvate + L-serine
-
 r
L-leucine + phenylpyruvate
-
 Mus musculus 4-methyl-2-oxopentanoate + L-phenylalanine
-
 ?
L-leucine + phenylpyruvate
-
 Rattus norvegicus 4-methyl-2-oxopentanoate + L-phenylalanine
-
 ?
L-methionine + pyruvate
-
 Mus musculus 4-methylsulfanyl-2-oxobutanoate + L-alanine
-
 ?
L-methionine + pyruvate
-
 Rattus norvegicus 4-methylsulfanyl-2-oxobutanoate + L-alanine
-
 ?
L-phenylalanine + pyruvate
-
 Mus musculus phenylpyruvate + L-alanine
-
 ?
L-phenylalanine + pyruvate
-
 Rattus norvegicus phenylpyruvate + L-alanine
-
 ?
L-serine + glyoxylate
-
 Mus musculus glycine + 3-hydroxypyruvate
-
 r
L-serine + glyoxylate
-
 Rattus norvegicus glycine + 3-hydroxypyruvate
-
 r
L-serine + glyoxylate
-
 Canis lupus familiaris glycine + 3-hydroxypyruvate
-
 r
L-serine + glyoxylate
-
 Felis catus glycine + 3-hydroxypyruvate
-
 r
L-serine + phenylpyruvate
-
 Mus musculus 3-hydroxypyruvate + L-phenylalanine
-
 r
L-serine + phenylpyruvate
-
 Rattus norvegicus 3-hydroxypyruvate + L-phenylalanine
-
 r
L-serine + phenylpyruvate little activity detected Canis lupus familiaris 3-hydroxypyruvate + L-phenylalanine
-
 r
L-serine + phenylpyruvate little activity detected Felis catus 3-hydroxypyruvate + L-phenylalanine
-
 r
L-serine + pyruvate
-
 Mus musculus 3-hydroxypyruvate + L-alanine
-
 r
L-serine + pyruvate
-
 Rattus norvegicus 3-hydroxypyruvate + L-alanine
-
 r
L-serine + pyruvate
-
 Canis lupus familiaris 3-hydroxypyruvate + L-alanine
-
 r
L-serine + pyruvate
-
 Felis catus 3-hydroxypyruvate + L-alanine
-
 r
L-serine + pyruvate gluconeogenesis from serine Mus musculus 3-hydroxypyruvate + L-alanine
-
 r
L-serine + pyruvate gluconeogenesis from serine Rattus norvegicus 3-hydroxypyruvate + L-alanine
-
 r
L-serine + pyruvate gluconeogenesis from serine Canis lupus familiaris 3-hydroxypyruvate + L-alanine
-
 r
L-serine + pyruvate gluconeogenesis from serine Felis catus 3-hydroxypyruvate + L-alanine
-
 r
L-tyrosine + pyruvate
-
 Mus musculus 3-(4-hydroxyphenyl)-2-oxopropanoate + L-alanine
-
 ?
L-tyrosine + pyruvate
-
 Rattus norvegicus 3-(4-hydroxyphenyl)-2-oxopropanoate + L-alanine
-
 ?
lysine + pyruvate
-
 Mus musculus 6-amino-2-oxohexanoate + alanine
-
 ?
additional information highly specific for serine as the amino donor Canis lupus familiaris ?
-
 ?
additional information highly specific for serine as the amino donor Felis catus ?
-
 ?
additional information 2-oxoglutarate, indol-3-ylpyruvate and p-hydroxyphenylpyruvate are no substrates Mus musculus ?
-
 ?
additional information 2-oxoglutarate, indol-3-ylpyruvate and p-hydroxyphenylpyruvate are no substrates Rattus norvegicus ?
-
 ?
additional information 2-oxoglutarate, indol-3-ylpyruvate and p-hydroxyphenylpyruvate are no substrates Canis lupus familiaris ?
-
 ?
additional information 2-oxoglutarate, indol-3-ylpyruvate and p-hydroxyphenylpyruvate are no substrates Felis catus ?
-
 ?
valine + pyruvate
-
 Mus musculus 3-methyl-2-oxobutanoate + alanine
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 36000-40000, SDS-PAGE Mus musculus
dimer 2 * 36000-40000, SDS-PAGE Rattus norvegicus
dimer 2 * 36000-40000, SDS-PAGE Canis lupus familiaris
dimer 2 * 36000-40000, SDS-PAGE Felis catus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5 9
-
 Mus musculus
8.5 9
-
 Rattus norvegicus
8.5 9
-
 Canis lupus familiaris
8.5 9
-
 Felis catus