Cloned (Comment) | Organism |
---|---|
overproduced in Escherichia coli | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-(cis-4-aminocyclohexa-2,5-dien-1-yl)propan-1-ol | suicide substrate, compound at 0.1 mg/l completely inhibits the growth of an Escherichia coli C268bioA mutant strain transformed with a plasmid expressing the Myobaterium tuberculosis bioA gene, coding for diaminopelargonic acid aminotransferase; suicide substrate, irreversible inhibition | Mycobacterium tuberculosis | |
8-Amino-7-oxononanoate | substrate inhibition | Mycobacterium tuberculosis | |
amiclenomycin | suicide substrate; suicide substrate, irreversible inhibition | Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0038 | - |
8-Amino-7-oxononanoate | - |
Mycobacterium tuberculosis | |
0.0038 | - |
8-Amino-7-oxononanoate | pH 8.6, 37°C | Mycobacterium tuberculosis | |
0.78 | - |
S-adenosyl-L-methionine | - |
Mycobacterium tuberculosis | |
0.78 | - |
S-adenosyl-L-methionine | pH 8.6, 37°C | Mycobacterium tuberculosis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
4 * 45000, SDS-PAGE | Mycobacterium tuberculosis |
189000 | - |
gel filtration | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Mycobacterium tuberculosis | P9WQ81 | - |
- |
Mycobacterium tuberculosis ATCC 25618 | P9WQ81 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Mycobacterium tuberculosis |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-(methylsulfanyl)-2-oxobutanoate + 7,8-diaminononanoate | enzyme shows a Ping Pong Bi Bi kinetic mechanism with strong substrate inhibition | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | - |
Mycobacterium tuberculosis | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | ping pong bi bi kinetic mechanism with strong substrate inhibition | Mycobacterium tuberculosis | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | - |
Mycobacterium tuberculosis ATCC 25618 | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | 4 * 45000, SDS-PAGE | Mycobacterium tuberculosis |
Synonyms | Comment | Organism |
---|---|---|
7,8-diaminoperlargonic acid aminotransferase | - |
Mycobacterium tuberculosis |
DAPA AT | - |
Mycobacterium tuberculosis |
diaminoperlargonic acid aminotransferase | - |
Mycobacterium tuberculosis |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.017 | - |
S-adenosyl-L-methionine | pH 8.6, 37°C | Mycobacterium tuberculosis | |
1 | - |
8-Amino-7-oxononanoate | - |
Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Mycobacterium tuberculosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.012 | - |
amiclenomycin | - |
Mycobacterium tuberculosis | |
0.012 | - |
amiclenomycin | pH 8.6, 37°C | Mycobacterium tuberculosis | |
0.014 | - |
8-Amino-7-oxononanoate | - |
Mycobacterium tuberculosis | |
0.014 | - |
3-(cis-4-aminocyclohexa-2,5-dien-1-yl)propan-1-ol | pH 8.6, 37°C | Mycobacterium tuberculosis | |
0.02 | - |
3-(cis-4-aminocyclohexa-2,5-dien-1-yl)propan-1-ol | - |
Mycobacterium tuberculosis | |
0.02 | - |
3-(cis-4-aminocyclohexa-2,5-dien-1-yl)propan-1-ol | pH 8.6, 37°C | Mycobacterium tuberculosis |