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Literature summary for 2.6.1.62 extracted from

  • Mann, S.; Ploux, O.
    7,8-Diaminoperlargonic acid aminotransferase from Mycobacterium tuberculosis, a potential therapeutic target. Characterization and inhibition studies (2006), FEBS J., 273, 4778-4789.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overproduced in Escherichia coli Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
3-(cis-4-aminocyclohexa-2,5-dien-1-yl)propan-1-ol suicide substrate, compound at 0.1 mg/l completely inhibits the growth of an Escherichia coli C268bioA mutant strain transformed with a plasmid expressing the Myobaterium tuberculosis bioA gene, coding for diaminopelargonic acid aminotransferase; suicide substrate, irreversible inhibition Mycobacterium tuberculosis
8-Amino-7-oxononanoate substrate inhibition Mycobacterium tuberculosis
amiclenomycin suicide substrate; suicide substrate, irreversible inhibition Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0038
-
8-Amino-7-oxononanoate
-
Mycobacterium tuberculosis
0.0038
-
8-Amino-7-oxononanoate pH 8.6, 37°C Mycobacterium tuberculosis
0.78
-
S-adenosyl-L-methionine
-
Mycobacterium tuberculosis
0.78
-
S-adenosyl-L-methionine pH 8.6, 37°C Mycobacterium tuberculosis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
4 * 45000, SDS-PAGE Mycobacterium tuberculosis
189000
-
gel filtration Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis P9WQ81
-
-
Mycobacterium tuberculosis ATCC 25618 P9WQ81
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mycobacterium tuberculosis

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-(methylsulfanyl)-2-oxobutanoate + 7,8-diaminononanoate enzyme shows a Ping Pong Bi Bi kinetic mechanism with strong substrate inhibition Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 8-amino-7-oxononanoate
-
Mycobacterium tuberculosis S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate ping pong bi bi kinetic mechanism with strong substrate inhibition Mycobacterium tuberculosis S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate
-
Mycobacterium tuberculosis ATCC 25618 S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 45000, SDS-PAGE Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
7,8-diaminoperlargonic acid aminotransferase
-
Mycobacterium tuberculosis
DAPA AT
-
Mycobacterium tuberculosis
diaminoperlargonic acid aminotransferase
-
Mycobacterium tuberculosis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.017
-
S-adenosyl-L-methionine pH 8.6, 37°C Mycobacterium tuberculosis
1
-
8-Amino-7-oxononanoate
-
Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Mycobacterium tuberculosis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.012
-
amiclenomycin
-
Mycobacterium tuberculosis
0.012
-
amiclenomycin pH 8.6, 37°C Mycobacterium tuberculosis
0.014
-
8-Amino-7-oxononanoate
-
Mycobacterium tuberculosis
0.014
-
3-(cis-4-aminocyclohexa-2,5-dien-1-yl)propan-1-ol pH 8.6, 37°C Mycobacterium tuberculosis
0.02
-
3-(cis-4-aminocyclohexa-2,5-dien-1-yl)propan-1-ol
-
Mycobacterium tuberculosis
0.02
-
3-(cis-4-aminocyclohexa-2,5-dien-1-yl)propan-1-ol pH 8.6, 37°C Mycobacterium tuberculosis