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Literature summary for 2.6.1.7 extracted from

  • Noguchi, T.; Minatogawa, Y.; Okuno, E.; Nakatani, M.; Morimoto, M.; Kido, R.
    Purification and characterization of kynurenine-2-oxoglutarate aminotransferase from the liver, brain and small intestine of rats (1975), Biochem. J., 151, 399-406.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.6.1.7

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by aspartate, tyrosine, phenylalanine Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-
soluble
-
 Rattus norvegicus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
100000
-
 isoenzyme 2, sucrose density gradient centrifugation Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Donryu
-
Rattus norvegicus
-
 isoenzyme 2
-
Rattus norvegicus Donryu
-
 Donryu
-

Purification (Commentary)

Purification (Comment) Organism
DEAE-cellulose, heat treatment, hydroxyapatite, CM-Sephadex C-25, Sephadex G-100 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.13
-
 isoenzyme 2 Rattus norvegicus
7.8
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-kynurenine + 2-oxoglutarate isoenzyme 2, no activity with L-tyrosine, L-phenylalanine, L-tryptophan, 5-hydroxy-L-tryptophan and L-aspartate Rattus norvegicus kynurenic acid + L-glutamate + H2O
-
 ?
L-kynurenine + 2-oxoglutarate isoenzyme 2, no activity with L-tyrosine, L-phenylalanine, L-tryptophan, 5-hydroxy-L-tryptophan and L-aspartate Rattus norvegicus Donryu kynurenic acid + L-glutamate + H2O
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 6.5
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Rattus norvegicus