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Literature summary for 2.6.1.7 extracted from
- Effects of calcium ions and quinolinic acid on rat kidney mitochondrial kynurenine aminotransferase (1974), Biochem. Biophys. Res. Commun., 60, 64-69.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EGTA | strong inhibition at pH 6.8 and Ca2+ concentrations below 0.5 mM | Rattus norvegicus |  |
| additional information | not inhibited by EGTA; not inhibited by quinolinate | Rattus norvegicus | |
| quinolinic acid | strong inhibition at pH 6.8 and Ca2+ concentrations below 0.5 mM | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| CaCl2 | approx. 4fold increase in activity at pH 6.4 | Rattus norvegicus | |
| additional information | not activated by chloride salts of Mg2+, Mn2+, Na+, K+ or NH4+ | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Sprague-Dawley | - |
| Rattus norvegicus Sprague-Dawley | - |
Sprague-Dawley | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-kynurenine + 2-oxoglutarate | - |
Rattus norvegicus | kynurenic acid + L-glutamate + H2O | - |
? | |
| L-kynurenine + 2-oxoglutarate | - |
Rattus norvegicus Sprague-Dawley | kynurenic acid + L-glutamate + H2O | - |
? | |
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Release 2023.1 (January 2023)
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