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Literature summary for 2.6.1.7 extracted from
- Purification and properties of kynurenine aminotransferase from rat kidney (1991), Biochem. J., 279, 595-599.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adipate | - |
Rattus norvegicus |  |
| azelaic acid | - |
Rattus norvegicus | |
| Decanoic acid | - |
Rattus norvegicus | |
| Diethylglutaric acid | - |
Rattus norvegicus | |
| dimethylglutaric acid | - |
Rattus norvegicus | |
| additional information | not inhibited by 2-aminoadipate; not inhibited by oxaloacetic acid, 3-methylglutaric acid | Rattus norvegicus | |
| pimelate | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.02 | - |
2-oxoglutarate | cosubstrate L-kynurenine | Rattus norvegicus | |
| 4 | - |
L-kynurenine | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
amino acid composition | Rattus norvegicus |
| 44000 | - |
2 * 44000, SDS-PAGE | Rattus norvegicus |
| 91000 | - |
gel filtration | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 4.22 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-3-hydroxykynurenine + 2-oxoglutarate | - |
Rattus norvegicus | xanthurenic acid + L-glutamate | - |
? | |
| L-histidine + 2-oxoglutarate | - |
Rattus norvegicus | 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate | - |
? | |
| L-kynurenine + 2-oxoglutarate | best substrates | Rattus norvegicus | kynurenic acid + L-glutamate + H2O | - |
? | |
| L-kynurenine + pyruvate | less effective than 2-oxoglutarate | Rattus norvegicus | kynurenic acid + L-alanine + H2O | - |
? | |
| L-tryptophan + 2-oxoglutarate | poor substrate | Rattus norvegicus | 3-indole-2-oxopropanoate + L-glutamate | - |
? | |
| L-tyrosine + 2-oxoglutarate | - |
Rattus norvegicus | 3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 44000, SDS-PAGE | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | not identical with EC 2.6.1.39 | Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
pI: 5.9 | Rattus norvegicus |
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Release 2023.1 (January 2023)
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