Inhibitors | Comment | Organism | Structure |
---|---|---|---|
glutamine | 0.08 mM; inhibition of KAT I | Homo sapiens | |
L-phenylalanine | inhibition of KAT I | Homo sapiens | |
L-tryptophan | inhibition of KAT I | Homo sapiens | |
additional information | KAT II is not inhibited by glutamine, tryptophan and phenylalanine | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
kynurenine aminotransferase I and II, i.e. KAT I and KAT II, in elderly Down syndrome patients | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | frontal and temporal cortex | Homo sapiens | - |
frontal lobe | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-kynurenine + 2-oxoglutarate | KAT I shows far higher activity with 2-oxoisohexanoate than with 2-oxoglutarate | Homo sapiens | kynurenic acid + L-glutamate + H2O | - |
? | |
L-kynurenine + 2-oxoisohexanoate | KAT I shows far higher activity with 2-oxoisohexanoate than with 2-oxoglutarate | Homo sapiens | kynurenic acid + 2-aminoisohexanoate + H2O | - |
? | |
L-kynurenine + pyruvate | KAT I shows far higher activity with 2-oxoisohexanoate and pyruvate than with 2-oxoglutarate | Homo sapiens | kynurenic acid + L-alanine + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
KAT I | - |
Homo sapiens |
KAT II | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | 8 | KAT II from brain | Homo sapiens |
9.6 | 10 | KAT I from brain, sharp optimum | Homo sapiens |