Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.6.1.7 extracted from

  • Okuno, E.; Nishikawa, T.; Nakamura, M.
    Kynurenine aminotransferases in the rat. Localization and characterization (1996), Adv. Exp. Med. Biol., 398, 455-464.
    View publication on PubMed
Search for more literature for 2.6.1.7

Inhibitors

Inhibitors Comment Organism Structure
3-hydroxykynurenine 2 mM, 50% inhibition of KAT I activity Rattus norvegicus
glutamine strong inhibition of KAT I, phenylpyruvate, 2-oxo-4-methiolbutyrate or 2-oxo-isocaproate protect Rattus norvegicus
L-cysteine inhibition of KAT I Rattus norvegicus
L-phenylalanine strong inhibition of KAT I Rattus norvegicus
S-dichlorovinyl-L-cysteine strong inhibition of KAT I Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
KAT I Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
heart KAT 1, low activity Rattus norvegicus
-
kidney KAT I and KAT II, major activity is performed by KAT II, KAT I contributes to 1/15 of total kynurenine aminotransferase activity Rattus norvegicus
-
liver KAT I Rattus norvegicus
-
lung KAT 1, low activity Rattus norvegicus
-
muscle KAT 1, low activity Rattus norvegicus
-
pancreas KAT I, low activity Rattus norvegicus
-
small intestine KAT 1, low activity Rattus norvegicus
-
spleen KAT 1, low activity Rattus norvegicus
-
stomach KAT 1, low activity Rattus norvegicus
-
testis KAT I, low activity Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-3-hydroxykynurenine + 2-oxoglutarate KAT I, no good substrate Rattus norvegicus xanthurenic acid + L-glutamate
-
 ?

Synonyms

Synonyms Comment Organism
kynurenine pyruvate aminotransferase i.e. KAT-I Rattus norvegicus
kynurenine-2-oxoglutarate aminotransferase i.e. KAT-II Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.3
-
 KAT I Rattus norvegicus