Literature summary for 2.6.1.81 extracted from

Vander Wauven, C.; Jann, A.; Haas, D.; Leisinger, T.; Stalon, V.
N2-Succinylornithine in ornithine catabolism of Pseudomonas aeruginosa (1988), Arch. Microbiol., 150, 400-404.

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Protein Variants

Protein Variants	Comment	Organism
additional information	aru mutants of strain PAO are unable to utilize L-arginine as the sole carbon and nitrogen source under aerobic conditions, while oru mutant strains are affected in ornithine utilization, oru- strains PAO968, PAO977, PAO2057, PAO958, and PAO961 show strongly reduced enzyme activity, while oru- strains PAO974, PAO957, PAO997, and PAO1007 have normal or elevated enzyme activity, overview	Pseudomonas aeruginosa

Inhibitors

Inhibitors	Comment	Organism	Structure
aminooxoacetic acid	leads to accumulation of succinyl-L-ornithine in vivo	Pseudomonas aeruginosa

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
additional information	-	additional information	specific activity in several aru mutant strains	Pseudomonas aeruginosa
0.42	-	N2-succinyl-L-ornithine	wild-type strain PAO1	Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
N2-succinyl-L-ornithine + 2-oxoglutarate	Pseudomonas aeruginosa	step in metabolic conversion of L-arginine into L-glutamate, pathway and regulation overview	N-succinyl-L-glutamate 5-semialdehyde + L-glutamate	-	?

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	gene aruC, wild-type strain PAO1	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N2-succinyl-L-ornithine + 2-oxoglutarate	-	Pseudomonas aeruginosa	N-succinyl-L-glutamate 5-semialdehyde + L-glutamate	-	?
N2-succinyl-L-ornithine + 2-oxoglutarate	step in metabolic conversion of L-arginine into L-glutamate, pathway and regulation overview	Pseudomonas aeruginosa	N-succinyl-L-glutamate 5-semialdehyde + L-glutamate	-	?

Synonyms

Synonyms	Comment	Organism
N2-succinylornithine 5-aminotransferase	-	Pseudomonas aeruginosa
SOAT	-	Pseudomonas aeruginosa
succinylornithine 5-aminotransferase	-	Pseudomonas aeruginosa

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Pseudomonas aeruginosa

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7	-	assay at	Pseudomonas aeruginosa

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)