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Literature summary for 2.6.1.83 extracted from
- Synthesis and structure-activity relationships of o-sulfonamido-arylhydrazides as inhibitors of LL-diaminopimelate aminotransferase (LL-DAP-AT) (2012), Org. Biomol. Chem., 10, 5815-5819.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-chloro-N-[5-fluoro-2-(hydrazinylcarbonyl)phenyl]benzenesulfonamide | - |
Arabidopsis thaliana |  |
| 4-fluoro-N-[5-fluoro-2-(hydrazinylcarbonyl)phenyl]benzenesulfonamide | - |
Arabidopsis thaliana | |
| N-[2-(hydrazinylcarbonyl)-4,5-dimethoxyphenyl]benzenesulfonamide | - |
Arabidopsis thaliana | |
| N-[2-(hydrazinylcarbonyl)-5-(trifluoromethyl)phenyl]benzenesulfonamide | - |
Arabidopsis thaliana | |
| N-[2-(hydrazinylcarbonyl)-5-methoxyphenyl]benzenesulfonamide | - |
Arabidopsis thaliana | |
| N-[2-(hydrazinylcarbonyl)-5-methylphenyl]benzenesulfonamide | - |
Arabidopsis thaliana | |
| N-[2-(hydrazinylcarbonyl)phenyl]benzenesulfonamide | - |
Arabidopsis thaliana | |
| N-[3-(hydrazinylcarbonyl)naphthalen-2-yl]benzenesulfonamide | - |
Arabidopsis thaliana | |
| N-[4,5-difluoro-2-(hydrazinylcarbonyl)phenyl]benzenesulfonamide | - |
Arabidopsis thaliana | |
| N-[5-chloro-2-(hydrazinylcarbonyl)phenyl]benzenesulfonamide | - |
Arabidopsis thaliana | |
| N-[5-fluoro-2-(hydrazinylcarbonyl)phenyl]-4-methoxybenzenesulfonamide | - |
Arabidopsis thaliana | |
| N-[5-fluoro-2-(hydrazinylcarbonyl)phenyl]-4-methylbenzenesulfonamide | - |
Arabidopsis thaliana | |
| N-[5-fluoro-2-(hydrazinylcarbonyl)phenyl]benzenesulfonamide | - |
Arabidopsis thaliana | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| LL-diaminopimelate + 2-oxoglutarate | - |
Arabidopsis thaliana | L-glutamate + tetrahydrodipicolinate + H2O | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LL-diaminopimelate aminotransferase | - |
Arabidopsis thaliana |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Arabidopsis thaliana | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0025 | - |
pH not specified in the publication, temperature not specified in the publication | Arabidopsis thaliana | N-[5-fluoro-2-(hydrazinylcarbonyl)phenyl]benzenesulfonamide | |
| 0.0034 | - |
pH not specified in the publication, temperature not specified in the publication | Arabidopsis thaliana | N-[5-fluoro-2-(hydrazinylcarbonyl)phenyl]-4-methoxybenzenesulfonamide | |
| 0.0038 | - |
pH not specified in the publication, temperature not specified in the publication | Arabidopsis thaliana | N-[2-(hydrazinylcarbonyl)-5-(trifluoromethyl)phenyl]benzenesulfonamide | |
| 0.0041 | - |
pH not specified in the publication, temperature not specified in the publication | Arabidopsis thaliana | N-[5-chloro-2-(hydrazinylcarbonyl)phenyl]benzenesulfonamide | |
| 0.0045 | - |
pH not specified in the publication, temperature not specified in the publication | Arabidopsis thaliana | N-[2-(hydrazinylcarbonyl)-5-methoxyphenyl]benzenesulfonamide | |
| 0.005 | - |
pH not specified in the publication, temperature not specified in the publication | Arabidopsis thaliana | N-[3-(hydrazinylcarbonyl)naphthalen-2-yl]benzenesulfonamide | |
| 0.0053 | - |
pH not specified in the publication, temperature not specified in the publication | Arabidopsis thaliana | 4-chloro-N-[5-fluoro-2-(hydrazinylcarbonyl)phenyl]benzenesulfonamide | |
| 0.0056 | - |
pH not specified in the publication, temperature not specified in the publication | Arabidopsis thaliana | N-[5-fluoro-2-(hydrazinylcarbonyl)phenyl]-4-methylbenzenesulfonamide | |
| 0.0059 | - |
pH not specified in the publication, temperature not specified in the publication | Arabidopsis thaliana | N-[4,5-difluoro-2-(hydrazinylcarbonyl)phenyl]benzenesulfonamide | |
| 0.0075 | - |
pH not specified in the publication, temperature not specified in the publication | Arabidopsis thaliana | 4-fluoro-N-[5-fluoro-2-(hydrazinylcarbonyl)phenyl]benzenesulfonamide | |
| 0.0079 | - |
pH not specified in the publication, temperature not specified in the publication | Arabidopsis thaliana | N-[2-(hydrazinylcarbonyl)-5-methylphenyl]benzenesulfonamide | |
| 0.0132 | - |
pH not specified in the publication, temperature not specified in the publication | Arabidopsis thaliana | N-[2-(hydrazinylcarbonyl)phenyl]benzenesulfonamide | |
| 0.0207 | - |
pH not specified in the publication, temperature not specified in the publication | Arabidopsis thaliana | N-[2-(hydrazinylcarbonyl)-4,5-dimethoxyphenyl]benzenesulfonamide | |
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