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Literature summary for 2.6.1.86 extracted from

  • Morollo, A.A.; Bauerle, R.
    Characterization of composite aminodeoxyisochorismate synthase and aminodeoxyisochorismate lyase activities of anthranilate synthase (1993), Proc. Natl. Acad. Sci. USA, 90, 9983-9987.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
chorismate + L-glutamine (2S)-2-amino-4-deoxychorismate is formed by a reversible, Mg2+-dependent ADIC synthase activity of anthranilate synthase (EC 4.1.3.27) that can be functionally uncoupled from a Mg2+-dependent ADIC lyase activity of the enzyme by single amino acid substitutions in the TrpE subunit of the anthranilate synthase complex of Salmonella typhimurium Salmonella enterica subsp. enterica serovar Typhimurium (2S)-2-amino-4-deoxychorismate + L-glutamate
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