Application | Comment | Organism |
---|---|---|
medicine | antibiotic-inactivating enzyme | Saccharothrix mutabilis subsp. capreolus |
medicine | antibiotic-inactivating enzyme | Streptomyces vinaceus |
Cloned (Comment) | Organism |
---|---|
shotgun cloning, resistance to viomycin is cloned into Streptomyces lividans, recombinant clones are cross resistant to capreomycin IA, but not to capreomycin IB | Streptomyces vinaceus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
ribosome | postribosomal supernatant (S100-fraction), intracellular or cytoplasmic membrane associated | Saccharothrix mutabilis subsp. capreolus | 5840 | - |
ribosome | postribosomal supernatant (S100-fraction), intracellular or cytoplasmic membrane associated | Streptomyces vinaceus | 5840 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + viomycin | Saccharothrix mutabilis subsp. capreolus | antibiotic-inactivating enzymes, involved in self-defence mechanism | ADP + O-phosphoviomycin | - |
? | |
ATP + viomycin | Streptomyces vinaceus | antibiotic-inactivating enzymes, involved in self-defence mechanism | ADP + O-phosphoviomycin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
no activity in Streptomyces coelicolor | - |
standard reference actinomycete, sensitive to viomycin and capreomycin | - |
no activity in Streptomyces coelicolor A | - |
standard reference actinomycete, sensitive to viomycin and capreomycin | - |
Saccharothrix mutabilis subsp. capreolus | - |
NCIB 9801 | - |
Streptomyces vinaceus | - |
NCIB 8852 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + capreomycin IA | capreomycin I B poor substrate | Saccharothrix mutabilis subsp. capreolus | ADP + O-phosphocapreomycin IA | - |
? | |
ATP + capreomycin IA | capreomycin I B poor substrate | Streptomyces vinaceus | ADP + O-phosphocapreomycin IA | - |
? | |
ATP + capreomycin IIA | - |
Saccharothrix mutabilis subsp. capreolus | ADP + O-phosphocapreomycin IIA | - |
? | |
ATP + capreomycin IIA | - |
Streptomyces vinaceus | ADP + O-phosphocapreomycin IIA | - |
? | |
ATP + viomycin | - |
Saccharothrix mutabilis subsp. capreolus | ADP + O-phosphoviomycin | - |
? | |
ATP + viomycin | - |
Streptomyces vinaceus | ADP + O-phosphoviomycin | - |
? | |
ATP + viomycin | antibiotic-inactivating enzymes, involved in self-defence mechanism | Saccharothrix mutabilis subsp. capreolus | ADP + O-phosphoviomycin | - |
? | |
ATP + viomycin | antibiotic-inactivating enzymes, involved in self-defence mechanism | Streptomyces vinaceus | ADP + O-phosphoviomycin | - |
? | |
additional information | a serine residue acts as phosphate-acceptor | Saccharothrix mutabilis subsp. capreolus | ? | - |
? | |
additional information | a serine residue acts as phosphate-acceptor | Streptomyces vinaceus | ? | - |
? | |
additional information | capreomycin IIB is no substrate | Streptomyces vinaceus | ? | - |
? |