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Literature summary for 2.7.1.105 extracted from

  • El-Maghrabi, M.R.; Fox, E.; Pilkis, J.; Pilkis, S.J.
    Cyclic AMP-dependent phosphorylation of rat liver 6-phosphofructo 2-kinase, fructose 2,6-bisphosphatase (1982), Biochem. Biophys. Res. Commun., 106, 794-802.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
beta-D-fructose 2,6-bisphosphate pH 7.5, 30°C Rattus norvegicus
0.1
-
beta-D-fructose 6-phosphate pH 7.5, 30°C Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
amino acid composition Rattus norvegicus
55000
-
2 * 55000, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Reaction

Reaction Comment Organism Reaction ID
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-D-fructose 6-phosphate
-
Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
r
additional information also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
dimer 2 * 55000, SDS-PAGE Rattus norvegicus

pI Value

Organism Comment pI Value Maximum pI Value
Rattus norvegicus ?
-
6.6