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Literature summary for 2.7.1.105 extracted from

  • Lypova, N.; Telang, S.; Chesney, J.; Imbert-Fernandez, Y.
    Increased 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 activity in response to EGFR signaling contributes to non-small cell lung cancer cell survival (2019), J. Biol. Chem., 294, 10530-10543 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine chemical enzyme PFKFB3 inhibition synergizes with erlotinib in increasing erlotinib s antiproliferative activity in NSCLC cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16875
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
lung cancer cell
-
 Homo sapiens
-
NCI-H522 cell
-
 Homo sapiens
-
non-small cell lung cancer cell
-
 Homo sapiens
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PC-9 cell
-
 Homo sapiens
-

Subunits

Subunits Comment Organism
? x * 50000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
PFKFB3 bifunctional enzyme with 6-phosphofructo-2-kinase and fructose-2,6-bisphosphatase activities Homo sapiens

General Information

General Information Comment Organism
metabolism enzyme PFKFB3 is an essential target of epidermal growth factor receptor signaling. PFKFB3 activation is required for glycolysis stimulation upon epidermal growth factor receptor activation. PFKFB3 has a key role in mediating glucose metabolism and survival of NSCLC cells in response to epidermal growth factor receptor signaling Homo sapiens