Literature summary for 2.7.1.107 extracted from

Merino, E.; Avila-Flores, A.; Shirai, Y.; Moraga, I.; Saito, N.; Merida, I.
Lck-dependent tyrosine phosphorylation of diacylglycerol kinase alpha regulates its membrane association in T cells (2008), J. Immunol., 180, 5805-5815.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in lymphocyte	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
Y335F	expression of wild-type diacylglycerol kinase alpha markedly reduces ERK phosphorylation, whereas the effect of expressing the nonphosphorylatableY335F mutant is much less pronounced	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	upon activation of T lymphocytes, diacylglycerol kinase alpha is phosphorylated, and the phosphoprotein is located at the plasma membrane	Homo sapiens	16020	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P23743	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	upon stimulation of T lymphocytes, diacylglycerol kinase alpha is phosphorylated at residue Y335 by Src kinase p56lck. Phosphorylation regulates translocation of enzyme to cell membrane	Homo sapiens

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Release 2023.1 (January 2023)