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Literature summary for 2.7.1.107 extracted from
- Diacylglycerol kinases in the regulation of dendritic spines (2010), J. Neurochem., 112, 577-587.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| dendrite | - |
Rattus norvegicus | 30425 | - |
| dendrite | - |
Mus musculus | 30425 | - |
| nucleus | a portion of intracellular DGKzeta protein is localized to the nucleus | Rattus norvegicus | 5634 | - |
| nucleus | a portion of intracellular DGKzeta protein is localized to the nucleus | Mus musculus | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q80UP3 | - |
- |
| Rattus norvegicus | O08560 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cerebellum | - |
Rattus norvegicus | - |
| cerebellum | - |
Mus musculus | - |
| hippocampus | - |
Rattus norvegicus | - |
| hippocampus | - |
Mus musculus | - |
| neuron | dendritic spines on neuronal dendrites | Rattus norvegicus | - |
| neuron | dendritic spines on neuronal dendrites | Mus musculus | - |
| olfactory bulb | - |
Rattus norvegicus | - |
| olfactory bulb | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1,2-diacylglycerol | - |
Rattus norvegicus | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? |  |
| ATP + 1,2-diacylglycerol | - |
Mus musculus | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DGKzeta | - |
Rattus norvegicus |
| DGKzeta | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
| ATP | - |
Mus musculus | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | DGKzeta mRNA levels are increased in mice on a high-fat diet, but are lower in those that become obese by a high-fat diet | up |
| Rattus norvegicus | DGKzeta mRNA levels are increased in rats on a high-fat diet, but are lower in those that become obese by a high-fat diet | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | knockdown of DGKfzeta in cultured neurons decreases spine density | Rattus norvegicus |
| malfunction | knockdown of DGKfzeta in cultured neurons decreases spine density | Mus musculus |
| physiological function | isoform DGKf appears to form a multi-protein complex with functionally related proteins to organize efficient 1,2-diacylglycerol and 1,2-diacyl-sn-glycerol 3-phosphate signaling pathways at excitatory synapses, the DGKzeta isoform at excitatory postsynaptic sites is critically involved in spine maintenance, DGKzeta promotes neurite outgrowth | Rattus norvegicus |
| physiological function | isoform DGKf appears to form a multi-protein complex with functionally related proteins to organize efficient 1,2-diacylglycerol and 1,2-diacyl-sn-glycerol 3-phosphate signaling pathways at excitatory synapses, the DGKzeta isoform at excitatory postsynaptic sites is critically involved in spine maintenance, DGKzeta promotes neurite outgrowth | Mus musculus |
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Release 2023.1 (January 2023)
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