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Literature summary for 2.7.1.108 extracted from

  • Keller, R.K.; Rottler, G.D.; Cafmeyer, N.; Adair, W.L.
    Subcellular localization and substrate specificity of dolichol kinase from rat liver (1982), Biochim. Biophys. Acta, 719, 118-125.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Rattus norvegicus 5737
-
endoplasmic reticulum
-
Rattus norvegicus 5783
-
lysosome
-
Rattus norvegicus 5764
-
membrane
-
Rattus norvegicus 16020
-
microsome
-
Rattus norvegicus
-
-
mitochondrion
-
Rattus norvegicus 5739
-
nucleus
-
Rattus norvegicus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + dolichol Rattus norvegicus enzyme can function in augmenting the steady-state levels of dolichyl phosphate by phosphorylating preexisting dolichol molecules CDP + dolichyl phosphate
-
?
CTP + dolichol Rattus norvegicus Sprague-Dawley enzyme can function in augmenting the steady-state levels of dolichyl phosphate by phosphorylating preexisting dolichol molecules CDP + dolichyl phosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
rat
-
Rattus norvegicus
-
Sprague-Dawley
-
Rattus norvegicus Sprague-Dawley
-
Sprague-Dawley
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.15
-
relative specific activity in the soluble fraction Rattus norvegicus
0.21
-
relative specific activity in the mitochondrial lysosomal fraction Rattus norvegicus
0.52
-
relative specific activity in the nuclear fraction Rattus norvegicus
3.8
-
relative specific activity in the microsomal fraction, rough and smooth endoplasmic reticulum are found to have higher specific activities than the Golgi fraction Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + dolichol pig liver dolichol as substrate, R,S-dolichol-11, dolichol-16, dolichol-19 Rattus norvegicus CDP + dolichyl phosphate
-
?
CTP + dolichol enzyme can function in augmenting the steady-state levels of dolichyl phosphate by phosphorylating preexisting dolichol molecules Rattus norvegicus CDP + dolichyl phosphate
-
?
CTP + dolichol pig liver dolichol as substrate, R,S-dolichol-11, dolichol-16, dolichol-19 Rattus norvegicus Sprague-Dawley CDP + dolichyl phosphate
-
?
CTP + dolichol enzyme can function in augmenting the steady-state levels of dolichyl phosphate by phosphorylating preexisting dolichol molecules Rattus norvegicus Sprague-Dawley CDP + dolichyl phosphate
-
?
CTP + ficaprenol
-
Rattus norvegicus CDP + ficaprenyl phosphate
-
?
CTP + ficaprenol
-
Rattus norvegicus Sprague-Dawley CDP + ficaprenyl phosphate
-
?
CTP + polyprenol polyprenol-16, alpha-trans-polyprenol-16, polyprenol-19 Rattus norvegicus CDP + polyprenyl phosphate
-
?
CTP + polyprenol polyprenol-16, alpha-trans-polyprenol-16, polyprenol-19 Rattus norvegicus Sprague-Dawley CDP + polyprenyl phosphate
-
?
additional information microsomal enzyme shows a marked preference for saturation of the alpha-isoprene, dolichol-16 and dolichol-19 are 2.5fold more active than the corresponding polyprenols, the enzyme is twice as active against naturally occurring polyprenol-16 (alpha-cis-isoprene) compared to synthetic alpha-trans-polyprenol-16, all-trans-2,3-dihydrosolanesol and solanesol are not substrates Rattus norvegicus ?
-
?
additional information microsomal enzyme shows a marked preference for saturation of the alpha-isoprene, dolichol-16 and dolichol-19 are 2.5fold more active than the corresponding polyprenols, the enzyme is twice as active against naturally occurring polyprenol-16 (alpha-cis-isoprene) compared to synthetic alpha-trans-polyprenol-16, all-trans-2,3-dihydrosolanesol and solanesol are not substrates Rattus norvegicus Sprague-Dawley ?
-
?