Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CTP + dolichol | Homo sapiens | DK1 is responsible for the final step of the de novo biosynthesis of dolichol phosphate | CDP + dolichyl phosphate | - |
? | |
CTP + dolichol | Homo sapiens | DK1 is responsible for the final step of the de novo biosynthesis of dolichol phosphate, defect in human DK1 affects the biosynthesis of dolichol phosphate by the disturbance of the final phosphorylation step, causes lethal phenotype with death in early infancy. | CDP + dolichyl phosphate | dolichyl phosphate is involved in several glycosylation reactions, such as N-glycosylation, glycosylphosphatidylinositol (GPI)-anchor biosynthesis, and C- and O-mannosylation | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
extracts gained from patient fibroblasts show remarkably lower enzyme activity than extracts from control cells, in comparison with controls, the decrease in activity was 94.5-98.6% for all patients | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CTP + dolichol | DK1 is responsible for the final step of the de novo biosynthesis of dolichol phosphate | Homo sapiens | CDP + dolichyl phosphate | - |
? | |
CTP + dolichol | a defect in dolichol phosphate biosynthesis causes a new inherited disorder with death in early infancy | Homo sapiens | CDP + dolichyl phosphate | - |
? | |
CTP + dolichol | DK1 is responsible for the final step of the de novo biosynthesis of dolichol phosphate, defect in human DK1 affects the biosynthesis of dolichol phosphate by the disturbance of the final phosphorylation step, causes lethal phenotype with death in early infancy. | Homo sapiens | CDP + dolichyl phosphate | dolichyl phosphate is involved in several glycosylation reactions, such as N-glycosylation, glycosylphosphatidylinositol (GPI)-anchor biosynthesis, and C- and O-mannosylation | ? |
Synonyms | Comment | Organism |
---|---|---|
DK1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
CTP | - |
Homo sapiens |