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Literature summary for 2.7.1.127 extracted from
- Activation by calmodulin of inositol-1,4,5-trisphosphate 3-kinase in guinea pig peritoneal macrophages (1987), Arch. Biochem. Biophys., 257, 363-369.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| chlorpromazine | calmodulin-antagonist, inhibits Ca2+-activated enzyme activity | Cavia porcellus |  |
| N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide | i.e. W-7, calmodulin-antagonist; inhibits Ca2+-activated enzyme activity | Cavia porcellus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Cavia porcellus | 5829 | - |
| soluble | - |
Cavia porcellus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | only together with calmodulin, completely reversible | Cavia porcellus | |
| Ca2+ | activation by Ca2+/calmodulin | Cavia porcellus | |
| Ca2+ | not activated by free Ca2+ | Cavia porcellus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Cavia porcellus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| peritoneal macrophage | - |
Cavia porcellus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.00029 | - |
- |
Cavia porcellus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Cavia porcellus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Cavia porcellus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
assay at | Cavia porcellus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Cavia porcellus | |
| Calmodulin | activation by Ca2+/calmodulin | Cavia porcellus | |
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