Cloned (Comment) | Organism |
---|---|
cloning and expression of the isoenzymes A, B and C in COS-7 cells, the 3 isoenzymes A, B and C can be distinguished by their localization on transfection in COS-7 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | InsP3 3-kinase dead mutant cells with much lower or undetectable enzyme activities, the N-terminal deletion mutant of InsP3 3-kinase A starting at Leu-133 and the N-terminal deletion mutant of InsP3 3-kinase B starting at Asp-483 are cytoplasmic | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | isoform C is totally cytoplasmic, the N-terminal deletion mutant of InsP3 3-kinase A starting at Leu-133 and the N-terminal deletion mutant of InsP3 3-kinase B starting at Asp-483 are cytoplasmic | Homo sapiens | 5737 | - |
cytoskeleton | isoform A associates with, isoform B | Homo sapiens | 5856 | - |
endoplasmic reticulum | isoform B | Homo sapiens | 5783 | - |
plasma membrane | isoform B | Homo sapiens | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | the 3 isoenzymes A, B and C can be distinguished by their sensitivity to Ca2+/calmodulin | Homo sapiens | |
Ca2+ | activation by Ca2+/calmodulin | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | Homo sapiens | role of the 3 isoforms as direct InsP3 metabolizing enzymes and direct regulators of Ca2+ responses to extracellular signals | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
3 isoenzymes: A, B and C | - |
Source Tissue | Comment | Organism | Textmining |
---|
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | role of the 3 isoforms as direct InsP3 metabolizing enzymes and direct regulators of Ca2+ responses to extracellular signals | Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
additional information | the 3 isoenzymes A, B and C can be distinguished by their N-terminal sequence, sensitivity to Ca2+/calmodulin and localization on transfection in COS-7 cells | Homo sapiens | ? | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
Calmodulin | activation by Ca2+/calmodulin | Homo sapiens | |
Calmodulin | the 3 isoenzymes A, B and C can be distinguished by their sensitivity to Ca2+/calmodulin | Homo sapiens |