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Literature summary for 2.7.1.127 extracted from

  • Kim, I.H.; Park, S.K.; Hong, S.T.; Jo, Y.S.; Kim, E.J.; Park, E.H.; Han, S.B.; Shin, H.S.; Sun, W.; Kim, H.T.; Soderling, S.H.; Kim, H.
    Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling (2009), J. Neurosci., 29, 14039-14049.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.127

Activating Compound

Activating Compound Comment Organism Structure
additional information enhanced inositol 1,4,5-trisphosphate 3-kinase A in the synaptic field by long-term potentiation induction in rat hippocampal neurons Mus musculus
additional information enhanced IP3K-A IR in the synaptic field by long-term potentiation induction in rat hippocampal neurons Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
generation of knock-out mice Mus musculus
generation of knock-out rats and point mutant, IP3K-A is overexpressed in DIV 22 hippocampal neurons by infection with adenovirus containing full-length IP3K-A Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
K262A the green fluorescent protein-inositol 1,4,5-trisphosphate 3-kinase A point mutant is generated by site-directed mutagenesis, point mutant lacks kinase activity Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ IP3K-A catalytic activity regulates calcium levels by modulating the metabolism of 1D-myo-inositol 1,4,5-trisphosphate Mus musculus
Ca2+ IP3K-A catalytic activity regulates calcium levels by modulating the metabolism of 1D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate Mus musculus reducing the influx of calcium released from endoplasmic reticulum via IP3 receptor signaling ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus reducing the influx of calcium released from endoplasmic reticulum via IP3 receptor signaling ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus P17105
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
dendritic cell
-
 Mus musculus
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hippocampal cell line
-
 Rattus norvegicus
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neuron
-
 Mus musculus
-
neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate reducing the influx of calcium released from endoplasmic reticulum via IP3 receptor signaling Mus musculus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5-trisphosphate reducing the influx of calcium released from endoplasmic reticulum via IP3 receptor signaling Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
inositol 1,4,5-trisphosphate 3-kinase A
-
 Mus musculus
inositol 1,4,5-trisphosphate 3-kinase A
-
 Rattus norvegicus
IP3K-A
-
 Mus musculus
IP3K-A
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus overexpression of IP3K-A in DIV 22 hippocampal neurons by infection with adenovirus containing full-length inositol 1,4,5-trisphosphate 3-kinase A leads to a markedly increased number of dendritic structure 18 h after infection, overexpressed GFP-IP3K-A signals are highly localized in the heads of dendritic protrusions additional information

General Information

General Information Comment Organism
malfunction enzyme knock-out mice show deficits of synaptic plasticity in perforant path and in hippocampal-dependent memory performances Mus musculus
physiological function on neural activation, inositol 1,4,5-trisphosphate 3-kinase A binds directly to activated Rac1 and recruits it to the actin cytoskeleton in the postsynaptic area, enzyme is critical for the spatial and temporal regulation of spine actin remodeling, synaptic plasticity, and learning and memory via an activity-dependent Rac scaffolding mechanism, inositol 1,4,5-trisphosphate 3-kinase A catalytic activity regulates calcium levels by modulating the metabolism of 1D-myo-inositol 1,4,5-trisphosphate Mus musculus
physiological function on neural activation, inositol 1,4,5-trisphosphate 3-kinase A binds directly to activated Rac1 and recruits it to the actin cytoskeleton in the postsynaptic area, enzyme is critical for the spatial and temporal regulation of spine actin remodeling, synaptic plasticity, and learning and memory via an activity-dependent Rac scaffolding mechanism, inositol 1,4,5-trisphosphate 3-kinase A catalytic activity regulates calcium levels by modulating the metabolism of 1D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus