Literature summary for 2.7.1.127 extracted from

Terhzaz, S.; Finlayson, A.J.; Stirrat, L.; Yang, J.; Tricoire, H.; Woods, D.J.; Dow, J.A.; Davies, S.A.
Cell-specific inositol 1,4,5 trisphosphate 3-kinase mediates epithelial cell apoptosis in response to oxidative stress in Drosophila (2010), Cell. Signal., 22, 737-748.

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Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	Q9VL83	isoform IP3K-1	-
Drosophila melanogaster	Q9VYE6	isoforms IP3K-2	-

Synonyms

Synonyms	Comment	Organism
IP3K1	-	Drosophila melanogaster
IP3K2	-	Drosophila melanogaster

General Information

General Information	Comment	Organism
physiological function	cell-specific inositol phosphate signalling specifically via inositol 1,4,5-trisphosphate 3-kinase, negatively regulates organismal responses to oxidative stress. The Drosophila malpighian tubule is a key epithelial sensor for organismal oxidative stress responses, precise targeting of either gain-of-function constructs of isoforms IP3K-1 and IP3K-2, or loss-of-function constructs to only one cell type in tubule reversibly modulates survival of stress-challenged adult flies	Drosophila melanogaster
physiological function	cell-specific inositol phosphate signalling specifically via inositol 1,4,5-trisphosphate 3-kinase, negatively regulates organismal responses to oxidative stress. The Drosophila malpighian tubule is a key epithelial sensor for organismal oxidative stress responses, precise targeting of either gain-of-function constructs of isoforms IP3K-1 and IP3K-2, or loss-of-function constructs to only one cell type in tubule reversibly modulates survival of stress-challenged adult flies. In vivo, targeted isoform IP3K-1 directly increases H2O2 production, pro-apoptotic caspase-9 activity and mitochondrial membrane potential. The mitochondrial calcium load in tubule principal cells is significantly increased by isoform IP3K-1 under oxidative stress conditions, leading to apoptosis	Drosophila melanogaster

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Release 2023.1 (January 2023)